DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIK3C2B and pik3c2b

DIOPT Version :9

Sequence 1:	NP_001364263.1	Gene:	PIK3C2B / 5287	HGNCID:	8972	Length:	1634	Species:	Homo sapiens
Sequence 2:	XP_003199535.1	Gene:	pik3c2b / 567938	ZFINID:	ZDB-GENE-050309-145	Length:	1587	Species:	Danio rerio

Alignment Length:	1667	Identity:	1041/1667 - (62%)
Similarity:	1243/1667 - (74%)	Gaps:	120/1667 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     2 SSTQGNGE-HWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGV 65
            :.||.:.| .|..|||:|:|:|||.:|||||||||||:|.|.||        ...|.:..|.
Zfish     4 AQTQNDREQRWGCLESLGLSQKELVLAEALQMEYDALARHRQDK--------GTSSTLPPDS--- 57

Human    66 DFYSKPAGRRTDLKLLR-------------GLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDP 117
               ||.:..|::..|.|             |:|||||.||:    .|.|..|.|.|.|...|...
Zfish    58 ---SKSSPSRSESSLPRRVPSPSWNNLQQQGVSGSDPMLNH----VQPGVSNLSRSSGESHGFTK 115

Human   118 WPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSP--PPL--PPRASIWDTPPLPPRKGSP 178
            .|:        ||.|..:         .|.:|:.:.||.  |.|  ||       ||:|||...|
Zfish   116 EPR--------YILDEWE---------SDFKGTSQMLSKGLPTLDEPP-------PPVPPRNPIP 156

Human   179 SSS-----KISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRL 238
            .:.     :.|.|.|:|.|:.....| ||             ..|:     :::||.:||:::::
Zfish   157 QNDPFIVHRSSAPRDVNLFTPEVDQP-KL-------------SFGE-----TLNYDNLNDSLSKI 202

Human   239 NLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATP-- 301
            |              ..|.........:.|.|||.||||.|:|||:|||||.        .||
Zfish   203 N--------------GDWLSPGRSRRANGDKSGKAVARSNTLPPQIPPRTYL--------PTPKS 245

Human   302 -GKNRRISAAPV--GSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFL-TGYVW 362
             ...||:|..||  ||||:  ..|:|||:||||||||||||||:||:|||.....||.. :|:||
Zfish   246 TRSQRRVSVDPVSLGSRPN--GFGYELFQVSEERDEEVAAFCHVLDLLRSAYPCNDYSKNSGFVW 308

Human   363 SAVTPSPE-HLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVL 426
            |......| ..|..|::||||..|..:|.|||:|:.|||:||||||||||.||||..:||.|::|
Zfish   309 SPCVAQDELQQGLGVSIKVTVYSDHFREPLTFSCDGSSTIDLLIYQTLCYAHDDLDMIDVDDYLL 373

Human   427 KPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQ 491
            |.|...|||:|...|.|.||||.|.|||.||||.|.::..|..:||||..||.:|||:|:.:.||
Zfish   374 KICSQAEFLKNTQTLASFEYIQQCLKFDWDIRLILTKRSSVNMELARTTEDDDTPSTMNHSILLQ 438

Human   492 ERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALN 556
            |||:|||::::||:||.||:|||.::|||::.:.||..:|:||||||:|.:|||||||:||:|||
Zfish   439 ERPIKQTVTKEALTLLLDTFHNEAESFLLSEVELPLHVERLVQSVKALCTSLAAVETPDITAALN 503

Human   557 QLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLV 621
            |||.||.|:|||:|||.||||.:|||..:||.|||||||||||||:||||:|.|....||....:
Zfish   504 QLPACPCRLQPKVQKDVSVLAKKENRVAIVEKLTAAILDLVELYCSTFNANFHTMPHSSRSTAPI 568

Human   622 QEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVW 686
            |||......|:|:|||.||:||.||.|||:|:|||||:|||.|||:|..|.:...|||||||:||
Zfish   569 QEAGMVTNVLSFSVYAAHRVPITWAASYENFFLSCSLTHGGVELCAPQHTSKQSVSKYLFHLVVW 633

Human   687 DQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGR 751
            ||::|||||:|:||||:.|..||||.|:||||.:.|.:||:|..|:|||||.||||||.||||||
Zfish   634 DQRVCFPVQINQLPRESQLTVTLYATPLPPPGGAEEKSKQKRSIESLGWVTMPLFNFRHVLTCGR 698

Human   752 KLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQ 816
            |||||||:|..:.:||.|.|||.||||||||:|||||:|:::|::|...:|||:|||..|.:..|
Zfish   699 KLLGLWPSTPGSGNARSSTPNFSQPDSVILQVDFPTSSFEVRFSTPAPAEFSPQYEFSHLDQVSQ 763

Human   817 RKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHM 881
            |:|.|::.|:||:||:..|::.||||||:||.|.|.||||||||||||||||||||.||:||..|
Zfish   764 RQLHDVLHKKSLFWLSPEDRRLLWEKRYFCHVEASRLPLVLASAPSWEWACLPDIYALLRQWGCM 828

Human   882 NHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVS 946
            ||.||||||:|||||||.||.||||:.|:||.||||:||||||||||||||||.||||||:||:.
Zfish   829 NHLDALGLLNATFPDQECRRTAVQWMDSISDPELLDFLPQLVQALKYECYLDSHLVRFLLRRAIG 893

Human   947 DLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAA 1011
            |:|:.||.||||||.|:|||||:||||||||||||.|:||||||:|||||||.|||:||:||||:
Zfish   894 DVRIAHYLFWLLKDTLQDSQFSVRYQYLLAALLCCSGRGLREEFDRQCWLVNVLAKVAQRVREAS 958

Human  1012 PSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGE 1076
            ||:||.|||.||::|||||::|.||||||:|.||||||..:.|||||||||||||||||.|.||:
Zfish   959 PSSRQAILREGLDDVKQFFSINSSCRLPLNPGLLVKGINIQSCSYFNSNAVPLKLSFQNQDHLGD 1023

Human  1077 NIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKI 1141
            ||.||||.||||||||||||:||||:|||||||||||||||||||||||||||||||:|||||||
Zfish  1024 NINVIFKAGDDLRQDMLTLQIIRIMNKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPSAETLRKI 1088

Human  1142 QVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTT 1206
            ||||||||||||||||||||||||.|:|||||||||||||||||||||:|||||||||||||||:
Zfish  1089 QVEHGVTGSFKDRPLADWLQKHNPTEEEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTS 1153

Human  1207 GHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKH 1271
            |||||||||:||||||||||||||||||||||||||||||||||||||||||||||:|||.||||
Zfish  1154 GHMFHIDFGKFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCEAYNRIRKH 1218

Human  1272 THLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIH 1336
            .||||||||||||.|||||||::|||||||||||.::||:||.:|||||||||||||||||||||
Zfish  1219 AHLFLNLLGLMLSSGIPELSDVDDLKYVYDALRPHESEADATMHFTRLIESSLGSVATKLNFFIH 1283

Human  1337 NLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTH-EAT 1400
            |||||||..|::|..||||.|.:|:|:.|.|..:|:|||.|.:.|:|||.|||||.||... ..|
Zfish  1284 NLAQMKFASSEERPVLSFAPRVYTMKTDGVIRSLFVCRHIKTYSPSKGYSYVVKVEREGQQGSPT 1348

Human  1401 YIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVA 1465
            .:|||||||.|||:||:|:||||.|||||||||||||||||:|:||::|||||:||||||..|||
Zfish  1349 LVQRTFEEFNELHSKLQLIFPSSKLPSFPSRFVIGRSRGEALADRRKDELNGYVWHLIHAAQEVA 1413

Human  1466 ECDLVYTFFHPLPRDEKA--MG--TSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHI 1526
            :|||:|||||||||||:|  :|  .:...|.:|.:||...|.:.||||||:.||::|||||||||
Zfish  1414 QCDLIYTFFHPLPRDERAGSVGNVVNTLHKPTDVSWAPVPGAMAGEVKLSVLYKSDKLFIMVMHI 1478

Human  1527 RGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLS 1591
            ||||.||||.|||||||:|||||||||:|||||.||:|||||||||||||.||:||||||.:.|.
Zfish  1479 RGLQPLQDGTDPDPYVKLYLLPDPQKTSKRKTKAARRTCNPTYNEMLVYDKIPRGDLQQRTVHLR 1543

Human  1592 VLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGT 1633
            ||||..||||.||||..|.|::|........|..||:|...|
Zfish  1544 VLSEGAFWENTLLGETIIHLKDLTPGHRWVDWHQLGTRGSDT 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIK3C2B	NP_001364263.1	Interaction with GRB2. /evidence=ECO:0000269\|PubMed:11533253	2..298		99/318 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..188		42/164 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..315		25/60 (42%)
		PI3K_rbd	364..466	CDD:395642	55/102 (54%)
		C2A_PI3K_class_II	622..794	CDD:175979	112/171 (65%)
		PI3Ka_II	813..981	CDD:238441	123/167 (74%)
		PI3Kc_C2_beta	987..1340	CDD:119421	308/352 (88%)
		PX_PI3K_C2_beta	1369..1477	CDD:132823	76/108 (70%)
		C2B_PI3K_class_II	1505..1627	CDD:176027	86/121 (71%)
pik3c2b	XP_003199535.1	PI3K_rbd	322..413	CDD:295323	53/90 (59%)
		C2A_PI3K_class_II	569..741	CDD:175979	112/171 (65%)
		PI3Ka	763..928	CDD:294194	123/164 (75%)
		PI3Kc_C2_beta	934..1287	CDD:119421	308/352 (88%)
		PX_domain	1317..1425	CDD:295365	76/107 (71%)
		C2B_PI3K_class_II	1458..1579	CDD:176027	86/120 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327592
Domainoid	1	1.000	422	1.000	Domainoid score	I4105
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20582
Inparanoid	1	1.050	2017	1.000	Inparanoid score	I448
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49277
OrthoDB	1	1.010	-	-		D17088at7742
OrthoFinder	1	1.000	-	-		FOG0001789
OrthoInspector	1	1.000	-	-		oto43454
orthoMCL	1	0.900	-	-		OOG6_104124
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3211
SonicParanoid	1	1.000	-	-		X2272
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300