DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP6V1C1 and vma5

DIOPT Version :9

Sequence 1:	NP_001686.1	Gene:	ATP6V1C1 / 528	HGNCID:	856	Length:	382	Species:	Homo sapiens
Sequence 2:	NP_593891.1	Gene:	vma5 / 2543469	PomBaseID:	SPAPB2B4.05	Length:	394	Species:	Schizosaccharomyces pombe

Alignment Length:	398	Identity:	115/398 - (28%)
Similarity:	218/398 - (54%)	Gaps:	25/398 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     2 TEFWLISAPGE-----KTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKL 61
            ::||::|.|..     ..|... |:| ..:...:.::..:.|::|..||.:||||:..|::|.|.
pombe     4 SDFWILSVPSRGGSNADLCDDI-ERL-LVSGSTSLISTVAPFDVPPFKVESLDVLISQSEQLTKQ 66

Human    62 DAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIA 126
            ||.....:.|::..:.:.:..|...:::..:......:.|::.|.|:.:::.:.:::..||:.|.
pombe    67 DAQCASAISKISDIIKNTVSSSSGDLKDYFMVQDKSPLEYVSSFAWNSSRFHMNKTISEISDRIT 131

Human   127 KGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPK 191
            ..:...:||:::|.:::.......||:::|.:|:|..:|||.||.::|.|..|:||..:.:.||.
pombe   132 SEIISFENDIRTRQTSFQQASSAFQNMQKKQSGNLSQKSLANIVHEEDVVHGSDYLTNVFIAVPL 196

Human   192 LNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEE 256
            .....::..||||.::|:|||:..|.:|.:..|..|.:|:|..|.|..||||.|:.:|:|.:.:.
pombe   197 NLEKQFLNSYETLTDLVIPRSAKKLDQDSEFVLYTVVVFKKTADSFITKAREAKYTIREFTFEQG 261

Human   257 EMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLL 321
            ..:.::.|.:..:..:|:....|:|:..:.|||:|..|||:|.|.|:|||:||||||.:|.:::.
pombe   262 LRETEQSEFDDAAVKEKRMLSSLLRYASIAFSESFQGWIHLKCLCVYVESILRYGLPPDFSSVIF 326

Human   322 QPNKKTLKKLREVLHELY-------------KHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYK 373
            ||..|:..|::.:|...|             |::||||.  :|..|  ..||| .:||.|:|.:.
pombe   327 QPMAKSEVKIKNILLSKYAYLAQNPVGNNKVKNVDSSAG--LDESM--ADLNL-DEEYLPFVLFT 386

Human   374 IDCNLLEF 381
            :...:..:
pombe   387 VPSKVFNY 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C1	NP_001686.1	V-ATPase_C	5..370	CDD:397366	113/382 (30%)
		3-helical coiled coil	56..76	CDD:270211	5/19 (26%)
		3-helical coiled coil	121..147	CDD:270211	6/25 (24%)
		3-helical coiled coil	275..306	CDD:270211	13/30 (43%)
vma5	NP_593891.1	COG5127	1..394	CDD:227456	115/396 (29%)
		3-helical coiled coil	61..81	CDD:270211	5/19 (26%)
		3-helical coiled coil	126..152	CDD:270211	6/25 (24%)
		3-helical coiled coil	280..311	CDD:270211	13/30 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	216	1.000	Domainoid score	I660
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1281
Inparanoid	1	1.050	219	1.000	Inparanoid score	I1051
OMA	1	1.010	-	-		QHG54067
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		otm53952
orthoMCL	1	0.900	-	-		OOG6_101992
Panther	1	1.100	-	-	O	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.000