DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIGC and PIG-C

DIOPT Version :9

Sequence 1:	NP_002633.1	Gene:	PIGC / 5279	HGNCID:	8960	Length:	297	Species:	Homo sapiens
Sequence 2:	NP_001350858.1	Gene:	PIG-C / 38410	FlyBaseID:	FBgn0035435	Length:	312	Species:	Drosophila melanogaster

Alignment Length:	288	Identity:	108/288 - (37%)
Similarity:	164/288 - (56%)	Gaps:	22/288 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     9 TKEVKWQKVLYERQPFPDNYVDRRFLEELRKNIHARKYQYWAVVFESSVVIQQLCSVCVFVVIWW 73
            :|...|.|.||..:.:||||.|..||::||.|:|.|.|.:...:...:|:..|:..:..|::::.
  Fly     7 SKRQPWVKNLYSNREYPDNYTDASFLKDLRTNLHCRIYTFGEAIAGITVLNNQISCITGFLILYQ 71

Human    74 YMDEGLLAPHWLLGTGLASSLIGYVLFDLIDGGEGRKKSGQTRWA----DLKSALVFITFTYGFS 134
            .|....::|..:|......:.|||:.:      .||..|    ||    |.|:.:..:.|.|.||
  Fly    72 LMLSDSVSPTTILVPSCGITGIGYLCY------RGRSLS----WALLGEDSKTLVTVVLFGYLFS 126

Human   135 PVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHA 199
            |:|.|||:::||||||.|:.|:|||:|||..||.:.|:||..:|||.|||.::|||||||.|.||
  Fly   127 PMLHTLTQAISTDTIYTMTFFVLLGNLIFGHYGLDVAMVSKAVSLNAAIFGAICLASRLPTSYHA 191

Human   200 FIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTL-LFAFSAVGGLLSISAVGAVLFALLLMSISC 263
            |:::..|...|.|:|::.:      ...:.|..| :||...: .|..||.....|:|...:.|:.
  Fly   192 FVLLVEAAVFFVLYPIMTE------ANWHAGFMLPIFAICCM-ALYCISRPVLYLYASTTIFINF 249

Human   264 LCPFYLIRLQLFKENIHGPWDEAEIKED 291
            :|||..:..|.:|.|||||||||.::|:
  Fly   250 VCPFIFVWQQQYKFNIHGPWDEAIVEEN 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIGC	NP_002633.1	GPI2	14..284	CDD:283969	102/274 (37%)
PIG-C	NP_001350858.1	GPI2	12..270	CDD:310793	102/274 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152095
Domainoid	1	1.000	179	1.000	Domainoid score	I3554
eggNOG	1	0.900	-	-		E1_KOG3059
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7109
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3940
Isobase	1	0.950	-	0	Normalized mean entropy	S5235
OMA	1	1.010	-	-		QHG53701
OrthoDB	1	1.010	-	-		D1241278at2759
OrthoFinder	1	1.000	-	-		FOG0005002
OrthoInspector	1	1.000	-	-		oto89281
orthoMCL	1	0.900	-	-		OOG6_103319
Panther	1	1.100	-	-	LDO	PTHR12982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R516
SonicParanoid	1	1.000	-	-		X3536
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750