Protein Alignment PIGA and piga-1

DIOPT Version :10

• Sequence 1: NP_001427718.1
• Gene: PIGA / 5277
• HGNCID: 8957
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_495840.1
• Gene: piga-1 / 174386
• WormBaseID: WBGene00008431
• Length: 444
• Species: Caenorhabditis elegans
• Alignment Length: 486
• Identity: 232/486 - (47%)
• Similarity: 305/486 - (62%)
• Gaps: 62/486 - (12%)

Human    33 HNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTSGLKVYYLPLKVM 97
            ::|.:|||||.||.||||:|||.|:|||||.||:|:::||.||||||||||::||||||||..|.
 Worm     8 YSIALVSDFFCPNAGGVETHIYFLAQCLIELGHRVVVITHGYGNRKGIRYLSNGLKVYYLPFIVA 72

Human    98 YNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADV 162
            ||.:|..::..|:|.||.:.:||.|.|||.||:||::||:.|.....|||:|||||||||||||.
 Worm    73 YNGATLGSIVGSMPWLRKVLLRENVQIIHGHSTFSSLAHETLMIGGLMGLRTVFTDHSLFGFADA 137

Human   163 SSVLTNKL-LTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRR---H 223
            |::||||| |..||.:.:..||||||||||||||..|:|..||.||||::.:.||||  |.   :
 Worm   138 SAILTNKLVLQYSLINVDQTICVSYTSKENTVLRGKLDPNKVSTIPNAIETSLFTPD--RNQFFN 200

Human   224 DSITIVVVSRLVYRKVDKACSWYNTSFDPPNNCRVDVIYMKLSLREGIDLLSGIIPELCQKYPDL 288
            :..|||.:.||||||                               |.|||..|:|::|.::..:
 Worm   201 NPTTIVFLGRLVYRK-------------------------------GADLLCEIVPKVCARHKSV 234

Human   289 NFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAA 353
            .|||||:|||||.|||:.||::||:||.:||.|.|..|:.||.||.||:||||||||||:|||||
 Worm   235 RFIIGGDGPKRIELEEMLERFKLHERVVILGMLPHNQVKRVLNQGQIFINTSLTEAFCMSIVEAA 299

Human   354 SCGLQVVSTRVGGIPEVLP-ENLIILCEPSVKSLCEGLEKAIFQLKSGTLPAPENIHNIVKTFYT 417
            ||||.||||||||:||||| ...|.|.||....|.:.|.||:.:.:.|.|..|...|..|...|.
 Worm   300 SCGLHVVSTRVGGVPEVLPIGEFISLEEPVPDDLVDALLKAVDRREKGLLMDPTEKHEAVSKMYN 364

Human   418 WRNVAERTEKVYDRVSVEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWMTPDSII 482
            |.:||.||:.:|.: :||:  ....||.||..:.....|  |.::.:.....:||  |:|   ::
 Worm   365 WPDVAARTQVIYQK-AVES--EPTGRLGRLKGYYDQGIG--FGIMYIVVSCIIIF--WLT---VL 419

Human   483 DVAIDATGPRGAWTNNYSHSKRGGENNEISE 513
            |:              :...::.|.|::.||
 Worm   420 DL--------------FDSPRKNGTNDKTSE 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIGA	NP_001427718.1	None
piga-1	NP_495840.1	GT4_PIG-A-like	9..408	CDD:340827	223/436 (51%)