Protein Alignment PIGA and piga

DIOPT Version :10

• Sequence 1: NP_001427718.1
• Gene: PIGA / 5277
• HGNCID: 8957
• Length: 515
• Species: Homo sapiens
• Sequence 2: XP_002942607.3
• Gene: piga / 100158632
• XenbaseID: XB-GENE-996765
• Length: 492
• Species: Xenopus tropicalis
• Alignment Length: 505
• Identity: 380/505 - (75%)
• Similarity: 416/505 - (82%)
• Gaps: 42/505 - (8%)

Human    18 SRVSPGSLYTC----RTRTHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRK 78
            |..:|.|..||    ..|.|:|||||||||||:|||||||||||||||||||||||||||||:||
 Frog     8 SCTNPYSSATCDCHATPRFHSICMVSDFFYPNVGGVESHIYQLSQCLIERGHKVIIVTHAYGDRK 72

Human    79 GIRYLTSGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAK 143
            ||||||:|||||||||||||||||||||.|||||||:|||||||::|||||||||||||||||||
 Frog    73 GIRYLTNGLKVYYLPLKVMYNQSTATTLLHSLPLLRFIFVRERVSVIHSHSSFSAMAHDALFHAK 137

Human   144 TMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPN 208
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   138 TMGLHTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPN 202

Human   209 AVDPTDFTPDP-FRRHDSITIVVVSRLVYRKVDKACSWYNTSFDPPNNCRVDVIYMKLSLREGID 272
            |:||||||||| .|....||:||||||||||                               |||
 Frog   203 AIDPTDFTPDPKIRDRSRITVVVVSRLVYRK-------------------------------GID 236

Human   273 LLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFL 337
            ||.|||||:||:||:|:||||||||||||||||||||||||||||||||||:.||||||||.|||
 Frog   237 LLGGIIPEMCQRYPNLHFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHQQVRNVLVQGDIFL 301

Human   338 NTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTL 402
            ||||||||||||||.||||||||||||||||||||||.||||:|||||||.|||:||.:|.:|.|
 Frog   302 NTSLTEAFCMAIVEGASCGLQVVSTRVGGIPEVLPENFIILCKPSVKSLCSGLEQAINRLLAGEL 366

Human   403 PAPENIHNIVKTFYTWRNVAERTEK--VYDRVSVEAVLPMDKRLDRLISHCGPVTGYIFALLAVF 465
            .:||.||..|.||||||:|||||||  ||:||:.|.|||||:||:||:.|||.|||.||||.|:.
 Frog   367 LSPETIHRTVSTFYTWRDVAERTEKVCVYNRVAQEVVLPMDQRLERLVRHCGVVTGCIFALFAIV 431

Human   466 NFLFLIFLRWMTPDSIIDVAIDATGPRGAWTNNYSHSKRGGENNEISETR 515
            :||.|.|||||||||.||:|::||||.|||...||..::    :|::..|
 Frog   432 SFLLLNFLRWMTPDSSIDIAVNATGPNGAWLRQYSTERK----HELTRKR 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIGA	NP_001427718.1	None
piga	XP_002942607.3	GT4_PIG-A-like	28..429	CDD:340827	346/431 (80%)