Protein Alignment SERPINI2 and Spn88Ea

DIOPT Version :10

• Sequence 1: NP_006208.1
• Gene: SERPINI2 / 5276
• HGNCID: 8945
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_524954.2
• Gene: Spn88Ea / 49804
• FlyBaseID: FBgn0028984
• Length: 427
• Species: Drosophila melanogaster
• Alignment Length: 425
• Identity: 106/425 - (24%)
• Similarity: 189/425 - (44%)
• Gaps: 74/425 - (17%)

Human    10 LLLFFGSQASRCSAQKNTEFAVDLYQEVSLS-HKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQ 73
            |.|:.|.|          .|||.:...:..| ..:|:.|||......|.:...|:.|..::::.:
  Fly    34 LNLYKGQQ----------NFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAK 88

Human    74 TL-------KQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFF 131
            .|       |:...||    ::|:.......:.|....|:.|:.::......|.|    ..:...
  Fly    89 VLHLDWADSKEVVRSA----YILEKMNRKERQSKMPLEFSSADRIFFANDLHVTE----CARNRL 145

Human   132 QSAIKLVDFQ-DAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRK 195
            ...::.:||: ..:...:.|:.|:.::|..:|::|.|.:|..|.|||||.||.|.||.|..:|:.
  Fly   146 AEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKT 210

Human   196 EDTQLINF--TKKNGSTVKIPMMKA--LLRTKYGYFSESSLNYQVLELSYK-------------- 242
            |.|..:.|  :..|.|.|.:...|.  ||..      :..|...||:|.|:
  Fly   211 EKTVPMPFYTSPSNYSLVSMMQQKGTFLLNV------DEQLRAHVLQLPYRTVFESQEKEDSSPD 269

Human   243 -GDEFSLIIILPA-EGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSL 305
             ..:.|:::|||. ....:|:|...:.|..:...|.:....|:|:|||:|:.||:::...:|..:
  Fly   270 ENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKM 334

Human   306 NITEIFSGGC----DLSGITDS--SEVYVSQVTQKVFFEINEDGSEAATSTGIHI-----PVIMS 359
            .::::|....    ||:..|.|  ...:|:::      :::|:||.||.:|.:..     ||
  Fly   335 GVSKMFDESVATFDDLTSETISIGDSKHVAKI------KVDEEGSTAAAATVLFTYRSARPV--- 390

Human   360 LAQSQFIANHPFLFIMKHNPTESILFMGRVTNPDT 394
             ..::|..||||||::....:.||||.|...:|.|
  Fly   391 -EPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKT 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINI2	NP_006208.1	serpinI2_pancpin	23..392	CDD:381042	100/408 (25%)
Spn88Ea	NP_524954.2	serpin_crustaceans_chelicerates_insects	36..422	CDD:381059	103/419 (25%)