Protein Alignment SERPINI1 and Spn43Ab

DIOPT Version :10

• Sequence 1: NP_005016.1
• Gene: SERPINI1 / 5274
• HGNCID: 8943
• Length: 410
• Species: Homo sapiens
• Sequence 2: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Alignment Length: 399
• Identity: 101/399 - (25%)
• Similarity: 195/399 - (48%)
• Gaps: 33/399 - (8%)

Human     9 LLVLQSMATGATFPEEAIAD---LSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQK 70
            ||:|.:::...|...:|.||   |:.::||.:.|...:||::.||.:|..:|.:..:||:|.|..
  Fly     9 LLLLATVSQSKTVGYDAAADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTAS 73

Human    71 EIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAA 135
            |::..:   .|..|:..:..:...:...|.......::||::::.........|..:.::.|::.
  Fly    74 ELQQGL---RLGPGDADAVSQRSGSYQQALTRDNNFRLANNIYINENLEFKGSFRDVAQRQFDSN 135

Human   136 VNHVDF--SQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPEN 198
            ::.:||  ..|...|:.||:.|...||..:.|::.....:..|...::|.|.:...|:..||.:.
  Fly   136 IDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDK 200

Human   199 TRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVP 263
            |...||.......|::..|:....|.|.|.:  |.:|    :|:|:||:..:.||:|:|..::..
  Fly   201 TEKRSFRTGSGQSVKVDTMWTLQNFNYAEVN--SLDA----KVVELPYQNPDFSMLLLLPNRKDG 259

Human   264 LATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDN 328
            |.:|:..:..:.:.....::.:|||||.||:|:|...:.|:...|.||:..:|.:|.:...:
  Fly   260 LRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNM--- 321

Human   329 KEIFLSKAI----HKSFLEVNEEG----SEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRT 385
            ..:|:|..|    ||:.:||.|.|    .|...:.|:.:.|:      :...||||.|.|:.:
  Fly   322 YRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSK------KFEADHPFVFAIKYK-- 378

Human   386 GTILFMGRV 394
            .:|.|:|.:
  Fly   379 DSIAFIGHI 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINI1	NP_005016.1	serpinI1_NSP	23..394	CDD:381005	97/383 (25%)
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	96/381 (25%)