Protein Alignment SERPINI1 and Spn100A

DIOPT Version :10

• Sequence 1: NP_005016.1
• Gene: SERPINI1 / 5274
• HGNCID: 8943
• Length: 410
• Species: Homo sapiens
• Sequence 2: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 368
• Identity: 79/368 - (21%)
• Similarity: 167/368 - (45%)
• Gaps: 61/368 - (16%)

Human    69 QKEIRHSMGYDSLKNGEEFSFLKEFSNM--------VTAKESQYV----MKIANSL--FVQNGFH 119
            |:..|.......:||.||...::|...:        :||.|.:.|    .|:.|::  ..::|
  Fly   288 QQNKRSDQEESQIKNLEENETVQEEEKLAKIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDG-- 350

Human   120 VNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAV 184
             .:|.:..::.:. .:|:.|:.::::...:.|       |:.|..:.::.|...:.:.:.|.|.:
  Fly   351 -ADEIMLALESHL-PSVSRVNGARSLFQQDDI-------TSALSANSITGRSAGSKSKMLLFNGL 406

Human   185 YFKGNWKS---QFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPY 246
            |::|:|.:   |.|..:...|..|.:|  .|:.|||:.:|:|...:.....      .:||.:||
  Fly   407 YYRGSWANPFYQLRDGSDEFFFMTNED--AVKAPMMHARGKFQVADLPQVK------ARVLSLPY 463

Human   247 EGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQ----KVEVYLPRFTVEQEIDLKDVL 307
            |....::.:||..:...|:.    |.:||........|||    ::.:.:|:|.||:....:.:|
  Fly   464 ETSRYALCIVLPDETEGLSD----VISQLQTSDFLLAKKQFQMKELHISMPKFQVEETSRSEAML 524

Human   308 KALGITEIFIK-DANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVI 371
            |.:|:.::|.: :|.|:.||::.::.:.:.:....:.|:|.||.|.::|.....:|...:...|:
  Fly   525 KQMGLKKVFSRTEAQLSLLSEDPDVHVDEIVQFVNVRVDEGGSSANSLSAATMQARTPSVESTVL 589

Human   372 ----------------VDHPFFFLIRNRRTGTILFMGRVMHPE 398
                            |:.||.:.|.:.:...:|..|::..||
  Fly   590 PVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIYTPE 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINI1	NP_005016.1	serpinI1_NSP	23..394	CDD:381005	77/362 (21%)
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815
		serpin	<380..627	CDD:381000	59/265 (22%)