DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPINB5 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_002630.2	Gene:	SERPINB5 / 5268	HGNCID:	8949	Length:	375	Species:	Homo sapiens
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	115/373 - (30%)
Similarity:	189/373 - (50%)	Gaps:	31/373 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    14 DLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHF--ENVKDVPFGFQTVTSD 76
            ::::.|.:.....|::.||:.:.|.||:..:||:|.||.|:...|..  |:.:.|...:..:.:|
  Fly    20 EIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYGALLND 84

Human    77 VNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKG-----QINNSI 136
            :........|||..|:||:...:|:..:..:.:.|:..|.|::..      |.|     :||..:
  Fly    85 LQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISL------TNGPVAAERINQWV 143

Human   137 KDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNME 201
            .|.|.|..:.::...|:....|.|:|||.||.|:|..||..::|:...|:|....:.|||||...
  Fly   144 LDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQM 208

Human   202 ATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMAN 266
            .||.......::.::||||:.|.:|||.|.||::||    ||..:|     |.:..:..|  :..
  Fly   209 GTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVE----GLSALE-----EKIVGFARP--LVA 262

Human   267 AKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGM-SETKGVALSNVIHKVCLEITEDG 330
            .:|.|.:||||:|...:.|..||.||::.:|: |.||.||: ::..|..:|.|.||..||:.|:|
  Fly   263 KEVYLKLPKFKIEFRDELKETLEKLGIRELFT-DKSDLSGLFADKSGGKVSQVSHKAFLEVNEEG 326

Human   331 GDSIEVPGARILQH---KDELNADHPFIYIIRHNKTRNIIFFGKFCSP 375
            .::.......:...   ...|.|||||.::||...|  |.|.|:..||
  Fly   327 AEAAGATSVAVTNRAGFSTFLMADHPFAFVIRDANT--IYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINB5	NP_002630.2	maspin_like	4..375	CDD:239012	113/371 (30%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	113/368 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930