Protein Alignment SERPINA1 and Spn55B

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_524953.1
• Gene: Spn55B / 49803
• FlyBaseID: FBgn0028983
• Length: 374
• Species: Drosophila melanogaster
• Alignment Length: 379
• Identity: 120/379 - (31%)
• Similarity: 188/379 - (49%)
• Gaps: 40/379 - (10%)

Human    55 AEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEG 119
            |.|...|::.|:......|:.|||.||.|..|:...|::.:|.|||.:.|:|.....||  :.:.
  Fly    13 ARFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPPE--VAQT 75

Human   120 FQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDY 184
            ||.:|....  :|.| |...|.|::.||.:|...:...:|:.|||||.::||...:.|.:.||.:
  Fly    76 FQFVLEKYR--NSNL-LRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINFALNDAAAQAINAW 137

Human   185 VEKGTQGKIVDLVK--ELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKR 247
            |...|||||.:||.  ....:|...|:|.:.|||.|...|..:.|||:.|.|.:...||:..|.:
  Fly   138 VNAKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQ 202

Human   248 LGMFNIQHCKKLSSWVLLMKYLGNATAIF-FLPDEG-------------KLQHLENELT-HDIIT 297
            ...||....:.|....|.|.|..:..::| .||.|.             .|..|.::|| .::..
  Fly   203 KAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTVNLVDLADKLTVEEVHV 267

Human   298 KFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAP-LKLSKAVHKAV 361
            ||             ||..:..:.:|...|.||||||:|::.|:.|.:.|... :.:||.:|||.
  Fly   268 KF-------------PKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVSKVLHKAT 319

Human   362 LTIDEKGTEAAGA--MFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVV 413
            :.::|:|||||.|  |.:....|:.|.:.:.::||::::  .|.|:.||.|..|
  Fly   320 IEVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVI--WNKKNILFAGAFV 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	120/379 (32%)
		RCL	368..392		9/25 (36%)
Spn55B	NP_524953.1	serpin42Da-like	15..368	CDD:381065	117/372 (31%)