Protein Alignment SERPINA1 and nec

DIOPT Version :9

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_524851.1
• Gene: nec / 45908
• FlyBaseID: FBgn0002930
• Length: 476
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 110/404 - (27%)
• Similarity: 192/404 - (47%)
• Gaps: 40/404 - (9%)

Human    36 DTSHHDQDHPTFNKITP---NLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTH 97
            |.:..:...|..|:..|   .:..|:..|::::....:..|:.|||.|:....|::...:...|.
  Fly    86 DLTKREPVTPPPNRPPPVFSYMDRFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTF 150

Human    98 DEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLY 162
            .|:.:...|:...:..||..|...:..:.|...|    ||....::.:..|..|:...::..|.|
  Fly   151 RELQKAGEFSKNAMAVAQDFESVIKYKKHLEGAD----LTLATKVYYNRELGGVNHSYDEYAKFY 211

Human   163 HS---EAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLV--KELDRDTVFALVNYIFFKGKWERPF 222
            .|   ||  |:..:.::...:||.:|...|:.||.|||  .::|..|...|||.::|:|:||..|
  Fly   212 FSAGTEA--VDMQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEF 274

Human   223 EVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATA-IFFLPDE----G 282
            ...||...||........||.||....::.:....:|.:..|.:.|..:||: :..||:|    |
  Fly   275 ATMDTSPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTGLG 339

Human   283 K-LQHLE------NELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGA 340
            | ||.|.      |.:.|.:        .|:|.::.|||.......|:...|..||:.::|:..:
  Fly   340 KMLQQLSRPEFDLNRVAHRL--------RRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNS 396

Human   341 DLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPP---EVKFNKPFVFLMIEQN 402
            .::.:.:: |:::||.:.||.:.:.|.||||:.|.:.:.:|:|:||   |...|:||||.:  :.
  Fly   397 QVTKLMDQ-PVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAV--RT 458

Human   403 TKSPLFMGKVVNPT 416
            ..|.||:|.|..||
  Fly   459 PASVLFIGHVEYPT 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	alpha-1-antitrypsin_like	55..412	CDD:239011	103/376 (27%)
		RCL	368..392		10/26 (38%)
nec	NP_524851.1	SERPIN	108..468	CDD:238101	103/376 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7631
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960