Protein Alignment SERPINA1 and Spn43Ab

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Alignment Length: 365
• Identity: 88/365 - (24%)
• Similarity: 158/365 - (43%)
• Gaps: 16/365 - (4%)

Human    58 AFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEG-FQ 121
            |..||..:|....:.|:..||.:|.::.|:..:|.|..|..|:.:||.....:........| :|
  Fly    33 AADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQRSGSYQ 97

Human   122 ELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGD--TEEAKKQINDY 184
            :.|..    |:..:|  .|.::::|.|:....|.:..::.:.|....::|..  .:.....||..
  Fly    98 QALTR----DNNFRL--ANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRA 156

Human   185 VEKGTQGKIVDLVK-ELDRD-TVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKR 247
            |...|.|||.|::: ||..| |...:||.:.:...|::.|.:..||:..|......:|||..|..
  Fly   157 VATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWT 221

Human   248 LGMFNIQHCKKLSSWVLLMKYLG-NATAIFFLPD-EGKLQHLENELTHDIITKFLENEDRRSASL 310
            |..||......|.:.|:.:.|.. :.:.:..||: :..|:.|:..|:...:...:....::...:
  Fly   222 LQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNLLAEIGAMSQQKVEV 286

Human   311 HLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAV-HKAVLTIDEKGTEAAGA 374
            .|||.|:|....|:....:||:..:||...|...:..........|| |||.:.:.|.|.:....
  Fly   287 LLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLE 351

Human   375 MFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVN 414
            ..|.....|...:.:.:.||||.:  :...|..|:|.:.|
  Fly   352 TGLLKGLFSRSKKFEADHPFVFAI--KYKDSIAFIGHIAN 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	88/365 (24%)
		RCL	368..392		3/23 (13%)
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	88/365 (24%)