Protein Alignment SERPINA1 and Spn77Ba

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_649205.3
• Gene: Spn77Ba / 40234
• FlyBaseID: FBgn0262057
• Length: 450
• Species: Drosophila melanogaster
• Alignment Length: 454
• Identity: 112/454 - (24%)
• Similarity: 205/454 - (45%)
• Gaps: 62/454 - (13%)

Human     7 WGILLLAG--LCCLVPVSLAEDPQGDAAQ------------------KTDTSHHDQDHPTFN--- 48
            |..|||..  ||       :.|||.:.|.                  ::..||.......|:
  Fly    11 WIPLLLGAIFLC-------SADPQNNQAPLQLSVGNPLTAFTAPTAFQSGVSHIQSMRSNFDTDV 68

Human    49 --KITPNLAEFAFSLYRQLAHQSNSTN--IFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLT 109
              .|:..:.:||..|.::::.:....|  ...||.|:.:...:|..|::.:|.:::.:.|..|
  Fly    69 LVSISQGVQDFALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLRIN-- 131

Human   110 EIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDT 174
             :.:.::...::.....||...|.:::.|...::..:|..:.:.:.:.::. |:.:...|:| .:
  Fly   132 -VEDEKLRGAYKVWSSFLNITTSTIEVATLQAIYTGKGYPIKNNYRDAIQN-YNVQPMEVDF-YS 193

Human   175 EEAKKQINDYVEKGTQGKIVDLVKELDRDTVFA---LVNYIFFKGKWERPFEVKDTEEEDFHVDQ 236
            .::..|||:...:.|:|.|...:  |.:|...|   |::.::|||:|:.||....|.||.|..:.
  Fly   194 PDSVIQINEDTNRTTRGLIPYTI--LPQDVYGAKMFLLSSLYFKGQWKFPFNKTLTREEPFFSES 256

Human   237 VTTV-KVPMMKRLGMF-NIQHCKKLSSWVLLMKY--LGNATAIFFLPDEG-KLQHLENEL----T 292
            ...: |:|||.:...| .:.:.:.|..:||.:.|  ......|..||..| ||..:.|.|    .
  Fly   257 GEVIGKIPMMVQEANFAYVSNVEGLDGYVLELPYGTQDRLAMIVVLPKRGFKLNDVANNLKALGL 321

Human   293 HDIITKFLENEDRRS----ASLHLPKLSITGTYDLKSVLGQLGITKVF-SNGADLSGVTEEAPLK 352
            ..|:.:.....:|.|    ..:.:||......:.||.||.|:||..:| .|.|:|..::.....|
  Fly   322 RPILQRLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRMSSGLFAK 386

Human   353 LSKAVHKAVLTIDEKGTEAAGAMFLEAIP-MSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
            |  .||...:.:||:|| .|||:...|:. .:.||:...|:||.::::|:.|...||.|:|.||
  Fly   387 L--VVHSTKIIVDEQGT-TAGAVTEAALANKATPPKFLLNRPFQYMIVEKATGLLLFAGQVRNP 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	99/386 (26%)
		RCL	368..392		8/24 (33%)
Spn77Ba	NP_649205.3	serpin77Ba-like_insects	72..447	CDD:381062	97/384 (25%)