Protein Alignment SERPINA1 and Acp76A

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_524153.1
• Gene: Acp76A / 40078
• FlyBaseID: FBgn0015586
• Length: 388
• Species: Drosophila melanogaster
• Alignment Length: 386
• Identity: 72/386 - (18%)
• Similarity: 142/386 - (36%)
• Gaps: 84/386 - (21%)

Human    48 NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGL--NFNLTE 110
            |.|..|:   :|.|.|:: .:....|...|.::|......:......::::::...|  ||..:|
  Fly    19 NTIQQNV---SFQLIREI-DRYTPENFVLSVLNIEMILFEIHAAKAVESNNDLERSLIINFGYSE 79

Human   111 IPEAQIHEGFQELLRTLNQPDSQLQL----TTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNF 171
            ..:..:..|    ||......::.|:    .....|.||:.|:||::.|....|.|..
  Fly    80 ARQEVLDWG----LRYKKASSAKFQMANKVAVSQKLPLSQKLRLVNEVLMTSAKKYDV------- 133

Human   172 GDTEEAK--KQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGK-----WERPFEVKDTEE 229
              |::.:  |.:::::.....|.:.:.|:|   ..:.|..|.:...|.     |...|:   :|.
  Fly   134 --TKDVRPSKLMDEWLSSHLDGVLANFVQE---KKLNAGENIVAISGMTVTPLWASHFQ---SEI 190

Human   230 EDFHVDQVTT-------VKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGK---- 283
            ..:.|:...|       ..||||..|..|......: :..:.:.....|...:..||.:|.
  Fly   191 NRYFVNNPGTGYASKDPTCVPMMHSLSSFETMSTDE-AKGIYIPFSSANLGMLILLPRKGVTCKD 254

Human   284 -LQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTE 347
             |.:|.|::.       :|..|.:...|.||.......|::......:.|...|.:.|..|
  Fly   255 ILDNLNNQIN-------VEYNDHKDVHLLLPIFKEKFDYNIAKFFNGINIEDTFKDSAFKS---- 308

Human   348 EAPLKLS--KAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEV--------KFNKPFVFLM 398
            :|.:|::  :..|              |..|...:.:.:..::        :.|:||||::
  Fly   309 KAKIKINNFRVNH--------------GIRFQPILRLEVVDDIDTGKTETFEVNRPFVFVI 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	71/384 (18%)
		RCL	368..392		2/31 (6%)
Acp76A	NP_524153.1	serpin	28..369	CDD:476815	68/374 (18%)