Protein Alignment SERPINA1 and Spn53F

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001036553.1
• Gene: Spn53F / 36931
• FlyBaseID: FBgn0034195
• Length: 379
• Species: Drosophila melanogaster
• Alignment Length: 371
• Identity: 77/371 - (20%)
• Similarity: 145/371 - (39%)
• Gaps: 35/371 - (9%)

Human    61 LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEI----PEAQIHEGFQ 121
            ||..:.:..::.||.||...|.::...:.:|.:.|..::|.:.:::..|.:    |:.|     :
  Fly    26 LYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYKPKTQ-----K 85

Human   122 ELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVE 186
            ....::.:......||.   .::.:.:|:..::...::   |:|....|.....|...::|.:..
  Fly    86 IFAMSVKKAPVAKSLTR---FYVRQNMKMSTEYRVFMR---HTEGRARNIAFAREQLDEVNTFYS 144

Human   187 KGTQGKIVDLVKE--LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLG 249
            .....:|..:|||  ...::...|||.|||...|||.|..:.|...:|.|:...:|.:|||....
  Fly   145 HEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPREFRVNATKSVMIPMMHEDS 209

Human   250 MFNIQHCKKLSSWVLLMKYL-GNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHL 312
            .|.......|.:..:|:.:. |:...:...||: ..|..|:.:|....|.....|.......:.:
  Fly   210 KFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKLQAMNILSVARNLTMMDVFVGI 274

Human   313 PKLSITGTYDLKSVLGQLGITKVFSNGADLSGVT-EEAPLKLSKAVHKAVLTIDEKG-----TEA 371
            ||..|....:|.....::||..:|......|.:. .....::...:|.......|:|     |:.
  Fly   275 PKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGVIHVVTFEFQEQGIGTPSTDV 339

Human   372 AGAMFLEAIPMSIPPEVKF---NKPFVFLMIEQNTKSPLFMGKVVN 414
            .........     ..||:   ..||.|.:|: || |..|.|.|.:
  Fly   340 GNGSLTHTF-----NGVKYFLATHPFAFYIID-NT-SIYFAGHVTS 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	77/371 (21%)
		RCL	368..392		4/31 (13%)
Spn53F	NP_001036553.1	serpin42Dd-like_insects	20..379	CDD:381070	77/371 (21%)