Protein Alignment SERPINA1 and Spn31A

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_609341.1
• Gene: Spn31A / 34339
• FlyBaseID: FBgn0032178
• Length: 382
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 94/383 - (24%)
• Similarity: 161/383 - (42%)
• Gaps: 30/383 - (7%)

Human    51 TPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQ 115
            ||........:|..:|......|:..||:.:....::|.||:...|.:|:.:.|.........|:
  Fly     8 TPYDCHIGAGIYHSIATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQRFASNAK 72

Human   116 IHEGF-QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKK 179
            :...: .||.......|:.|||.  |.|.||....:.|.|.:..:..:|:.|..|:...||:.::
  Fly    73 MANFYAAELGNITTDADTFLQLQ--NRLMLSSESGVADDFQKIAQTYFHATAECVDLEQTEKLRR 135

Human   180 QINDYVEKGTQG---KIVDLVKELDRDTVFALV--NYIFFKGKWERPFEVKDTEEEDFHV-DQVT 238
            .|::.:.....|   |.:.:......:|:..|:  |   .:.||..||....|...:||. .||.
  Fly   136 HISEQILASVGGGSWKDIHVAGGSSANTLLLLLAAN---LQSKWFLPFSAYRTGLYEFHSGSQVK 197

Human   239 TVKVPMMKRLGMF-NIQHCKKLSSWVLLMKY--LGNATAIFFLPDE-GKLQHLENELTHDIITKF 299
            :  |||:....|| .....:.|.:..:.:.|  ....:.:..||:: |.||.||.:| ||:....
  Fly   198 S--VPMLFDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILPNQRGGLQELEKQL-HDLDLGA 259

Human   300 LENE-DRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLT 363
            |:.. ......:.|||.||.....|:..|.|||..::|:..|:...:...|.|.::..:.|..:.
  Fly   260 LQQRMQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIFAASANFKHLHASANLPIADVLQKLRIN 324

Human   364 IDEKGTEAA-----GAMFLEAIPMSIPPEVKF---NKPFVFLMIEQNTKSPLFMGKVV 413
            ::|.|:.:.     .|...:.|.:|.....||   :.||.|.:..:|.  ...||.||
  Fly   325 LNESGSGSGPELPKNATEYKPIVISNSSRQKFFRADHPFFFAIRSENV--TYLMGHVV 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	94/383 (25%)
		RCL	368..392		6/31 (19%)
Spn31A	NP_609341.1	serpin42Dd-like_insects	10..382	CDD:381070	92/381 (24%)