Protein Alignment SERPINA1 and serpina1

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001071226.1
• Gene: serpina1 / 322701
• ZFINID: ZDB-GENE-030131-1421
• Length: 429
• Species: Danio rerio
• Alignment Length: 434
• Identity: 176/434 - (40%)
• Similarity: 263/434 - (60%)
• Gaps: 31/434 - (7%)

Human     7 WGILLLAGLCC-----LVPVSLAEDPQG----DAAQKTDTSHH------DQDHPTF------NKI 50
            ||.:    .||     ||..:.|....|    |....|...||      |:.||:.      :.:
Zfish     2 WGNI----YCCAIAALLVATAWAAPHDGHVGHDHGSHTADHHHHLHHGKDEPHPSHKGVDACHLL 62

Human    51 TPNLAEFAFSLYRQLAH--QSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFN-LTEIP 112
            .|:.|:||||||::||.  .....|||||||.|:.|.::|::|.||.|..:|..||.:: ||  |
Zfish    63 APHNADFAFSLYKKLASNPDGQGKNIFFSPVGISMALSLLAVGAKASTLSQIYSGLGYSALT--P 125

Human   113 EAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEA 177
            | |::||::.||..|......:||..|.|:.:.:|.|:||:||:|.:..|:||||.|:|...|.|
Zfish   126 E-QVNEGYEHLLHMLGHSQDAMQLEAGAGVAIRDGFKVVDQFLKDAQHYYNSEAFGVDFSKPEIA 189

Human   178 KKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKV 242
            ..:||.::.:.|..||.::||:||.|||..|:||::|:||||:||:.|.|.:.||.|||.|||:|
Zfish   190 AAEINKFIARKTHDKITNMVKDLDADTVMMLINYMYFRGKWEKPFDAKLTHKADFKVDQDTTVQV 254

Human   243 PMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRS 307
            .||||.|.::|.......:.|:::.|.||.:.:..|||:||::.||..:....:..:.:...|.|
Zfish   255 DMMKRTGRYDIYQDPVNQTTVMMVPYKGNTSMMIVLPDDGKMKELEESICRHHLKNWHDKLFRSS 319

Human   308 ASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAA 372
            ..|.:||.||:.|..|..:|..:|:|..|::.||.||:|||..:|:|:.:|:||:::||||||||
Zfish   320 VDLFMPKFSISATSKLDGILKDMGMTDAFNDKADFSGMTEEVKVKVSQVLHQAVMSVDEKGTEAA 384

Human   373 GAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416
            ....:|.:|||:|..|..|:||:.|::|.:|.|.|||||:.|||
Zfish   385 AITTIEIMPMSLPDTVILNRPFLVLIVEDSTMSILFMGKITNPT 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	161/370 (44%)
		RCL	368..392		11/23 (48%)
serpina1	NP_001071226.1	serpinA_A1AT-like	65..429	CDD:381017	160/367 (44%)