Protein Alignment SERPINA1 and serpina1l

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001013277.3
• Gene: serpina1l / 321195
• ZFINID: ZDB-GENE-040721-3
• Length: 433
• Species: Danio rerio
• Alignment Length: 425
• Identity: 171/425 - (40%)
• Similarity: 257/425 - (60%)
• Gaps: 27/425 - (6%)

Human    16 CC-----LVPVSLAEDPQG----DAAQKTDTSHH------DQDHPTF------NKITPNLAEFAF 59
            ||     ||..:.|....|    |....|...||      |:.||:.      :.:.|:.|:|||
Zfish    11 CCAIAALLVATAWAAPHDGHEGHDHGSHTADHHHHLHHGKDEPHPSHKGVDACHLLAPHNADFAF 75

Human    60 SLYRQLAH--QSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFN-LTEIPEAQIHEGFQ 121
            |||::||.  .:...|||||||.|:.|.::|::|.|..|..:|..||.:: ||  || |::||::
Zfish    76 SLYKKLASNPDAQGKNIFFSPVGISMALSLLAVGAKGSTLSQIYSGLGYSALT--PE-QVNEGYE 137

Human   122 ELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVE 186
            .||..|......:||..|.|:.:.:|.|:||:||:|.:..|:||||.|:|...|.|..:||.::.
Zfish   138 HLLHMLGHSQDAMQLEAGAGVAIRDGFKVVDQFLKDAQHYYNSEAFGVDFSKPEIAAAEINKFIA 202

Human   187 KGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMF 251
            :.|..||.::||:||.|||..|:||::|:||||:.|:.|.|.:.||.|||.|||:|.||||.|.:
Zfish   203 RKTHDKITNMVKDLDADTVMMLINYMYFRGKWEKQFDAKLTHKADFKVDQDTTVQVDMMKRTGRY 267

Human   252 NIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLS 316
            :|.......:.||::.|.||.:.:..||::||::.||..:....:..:.:...|.|..|.:||.|
Zfish   268 DIYQDPVNQTTVLMVPYKGNTSMLIVLPNDGKMKELEESICRHHLKNWHDKLFRSSVDLFMPKFS 332

Human   317 ITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIP 381
            |:.|..|..:|..:|:|..|...||.||:|||..:::|:.:|:||:::||||||||....:|.:|
Zfish   333 ISATSKLDDILMDMGMTDAFDYKADFSGMTEEVKVRVSRVLHQAVMSVDEKGTEAAAITTIEIMP 397

Human   382 MSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416
            ||:|..|..|:||:.|::|.:|.|.|||||:.|||
Zfish   398 MSLPHTVILNRPFLVLIVEDSTMSILFMGKITNPT 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	158/370 (43%)
		RCL	368..392		11/23 (48%)
serpina1l	NP_001013277.3	serpinA_A1AT-like	69..433	CDD:381017	157/367 (43%)