Protein Alignment SERPINA1 and Serpina1

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001421270.1
• Gene: Serpina1 / 24648
• RGDID: 3326
• Length: 411
• Species: Rattus norvegicus
• Alignment Length: 417
• Identity: 289/417 - (69%)
• Similarity: 354/417 - (84%)
• Gaps: 6/417 - (1%)

Human     1 MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQL 65
            |..|:|.|:|||||||||.|..||||     ||:||||..||. ||:.||:.|||:|||||||:|
  Rat     1 MAPSISRGLLLLAGLCCLAPSFLAED-----AQETDTSQQDQS-PTYRKISSNLADFAFSLYREL 59

Human    66 AHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQP 130
            .||||::||||||:||.|||||||||:|.||..:|||||.||||:||||.||:.|..||:|||:|
  Rat    60 VHQSNTSNIFFSPMSITTAFAMLSLGSKGDTRKQILEGLEFNLTQIPEADIHKAFHHLLQTLNRP 124

Human   131 DSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVD 195
            ||:|||.||||||:::.||||:||||:||..||||||:|||.|:|||||.|||||||||||||||
  Rat   125 DSELQLNTGNGLFVNKNLKLVEKFLEEVKNNYHSEAFSVNFADSEEAKKVINDYVEKGTQGKIVD 189

Human   196 LVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLS 260
            |:|:||.||||||||||||||||:|||..:.|.:.|||||:.||||||||.|||||::.:|..||
  Rat   190 LMKQLDEDTVFALVNYIFFKGKWKRPFNPEHTRDADFHVDKSTTVKVPMMNRLGMFDMHYCSTLS 254

Human   261 SWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKS 325
            ||||:|.|||||||||.|||:||:||||..||.|:|::||.|...|||.|:.|||||:|||:||:
  Rat   255 SWVLMMDYLGNATAIFLLPDDGKMQHLEQTLTKDLISRFLLNRQTRSAILYFPKLSISGTYNLKT 319

Human   326 VLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKF 390
            :|..||||:||:|.|||||:||:||||||:||||||||:||:|||||||..:||:|||:||:|||
  Rat   320 LLSSLGITRVFNNDADLSGITEDAPLKLSQAVHKAVLTLDERGTEAAGATVVEAVPMSLPPQVKF 384

Human   391 NKPFVFLMIEQNTKSPLFMGKVVNPTQ 417
            :.||:|:::|..|:||||:|||::||:
  Rat   385 DHPFIFMIVESETQSPLFVGKVIDPTR 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	259/366 (71%)
		RCL	368..392		17/23 (74%)
Serpina1	NP_001421270.1	serpinA1_A1AT	44..411	CDD:381012	259/366 (71%)
		RCL	367..386		12/18 (67%)