Protein Alignment SERPINA1 and Serpina1e

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_033273.1
• Gene: Serpina1e / 20704
• MGIID: 891967
• Length: 413
• Species: Mus musculus
• Alignment Length: 419
• Identity: 263/419 - (62%)
• Similarity: 338/419 - (80%)
• Gaps: 7/419 - (1%)

Human     1 MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQL 65
            |..|:||.:|||||||||||..||||     .|:||||..||. |..::|..||.:||.||||:|
Mouse     1 MTPSISWCLLLLAGLCCLVPSFLAED-----VQETDTSQKDQS-PASHEIATNLGDFAISLYREL 59

Human    66 AHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQP 130
            .||||::|||||||||||||||||||:|.|||.:|||||.||||:..||.||..||.||:|||:|
Mouse    60 VHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHNSFQHLLQTLNRP 124

Human   131 DSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVD 195
            ||:|||:||||||::..||||:||||:.|..|.:|.|:|||.::|||||.|||:||||||||||:
Mouse   125 DSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVE 189

Human   196 LVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLS 260
            .||:|::||||.|.|||.|||||::||:.::|::.:||||:.||||||||...||.::.||..||
Mouse   190 AVKKLEQDTVFVLANYILFKGKWKKPFDPENTKQAEFHVDESTTVKVPMMTLSGMLDVHHCSTLS 254

Human   261 SWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKS 325
            ||||||.|.|||||:|.|||:||:||||..|..::|:|||.|..||.|.:|:|:|||:|.|:|::
Mouse   255 SWVLLMDYAGNATAVFLLPDDGKMQHLEQTLNKELISKFLLNRRRRLAQIHIPRLSISGNYNLET 319

Human   326 VLGQLGITKVFSNGADLSGVTEE-APLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVK 389
            ::..||||::|::||||||:||| ||||||:|||||||||||.|||||.|..|:...:|:||.:.
Mouse   320 LMSPLGITRIFNSGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAATVLQGGFLSMPPILH 384

Human   390 FNKPFVFLMIEQNTKSPLFMGKVVNPTQK 418
            ||:||:|::.|::::||||:||||:||.|
Mouse   385 FNRPFLFIIFEEHSQSPLFVGKVVDPTHK 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	234/367 (64%)
		RCL	368..392		11/23 (48%)
Serpina1e	NP_033273.1	serpinA1_A1AT	44..412	CDD:381012	234/367 (64%)
		RCL	368..387		6/18 (33%)