Protein Alignment SERPINA1 and Serpina1c

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_033271.1
• Gene: Serpina1c / 20702
• MGIID: 891969
• Length: 413
• Species: Mus musculus
• Alignment Length: 419
• Identity: 270/419 - (64%)
• Similarity: 340/419 - (81%)
• Gaps: 7/419 - (1%)

Human     1 MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQL 65
            |..|:|||:|||||||||||..||||     .|:||||..||. |..::|..||.:||.||||:|
Mouse     1 MTPSISWGLLLLAGLCCLVPSFLAED-----VQETDTSQKDQS-PASHEIATNLGDFAISLYREL 59

Human    66 AHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQP 130
            .||||::|||||||||||||||||||:|.|||.:|||||.||||:..||.||:.||.||:|||:|
Mouse    60 VHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRP 124

Human   131 DSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVD 195
            ||:|||:||||||::..||||:||||:.|..|.:|.|:|||.::|||||.|||:|||||||||.:
Mouse   125 DSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAE 189

Human   196 LVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLS 260
            .||:||:||||||.|||.|||||::||:.::|||.:||||:.||||||||...||.::.||..||
Mouse   190 AVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLDVHHCSTLS 254

Human   261 SWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKS 325
            ||||||.|.|||||:|.|||:||:||||..|:.::|:|||....||.|.:|.|:|||:|.|:||:
Mouse   255 SWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLKRPRRLAQIHFPRLSISGEYNLKT 319

Human   326 VLGQLGITKVFSNGADLSGVTEE-APLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVK 389
            ::..||||::|:|||||||:||| ||||||:||||||||:||.|||||.|..|.|:|.|:||.|:
Mouse   320 LMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTMDETGTEAAAATVLLAVPYSMPPIVR 384

Human   390 FNKPFVFLMIEQNTKSPLFMGKVVNPTQK 418
            |:.||:|::.|::|:||||:||||:||.|
Mouse   385 FDHPFLFIIFEEHTQSPLFVGKVVDPTHK 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	240/367 (65%)
		RCL	368..392		14/23 (61%)
Serpina1c	NP_033271.1	serpinA1_A1AT	44..412	CDD:381012	240/367 (65%)