Protein Alignment SERPINA1 and Serpina1b

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_033270.3
• Gene: Serpina1b / 20701
• MGIID: 891970
• Length: 413
• Species: Mus musculus
• Alignment Length: 419
• Identity: 269/419 - (64%)
• Similarity: 341/419 - (81%)
• Gaps: 7/419 - (1%)

Human     1 MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQL 65
            |..|:|||:||||||||:||..||||     .|:||||..||. |..::|..||.:||.||||:|
Mouse     1 MTPSISWGLLLLAGLCCMVPSFLAED-----VQETDTSQKDQS-PASHEIATNLGDFAISLYREL 59

Human    66 AHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQP 130
            .||||::|||||||||||||||||||:|.|||.:|||||.||||:..||.||:.||.||:|||:|
Mouse    60 VHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRP 124

Human   131 DSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVD 195
            ||:|||:||||||::..||||:||||:.|..|.:|.|:|||.::|||||.|||:||||||||||:
Mouse   125 DSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVE 189

Human   196 LVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLS 260
            .|||||:||||||.|||.|||||::||:.::|||.:||||:.||||||||...||.::.||..||
Mouse   190 AVKELDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDKSTTVKVPMMMLSGMLDVHHCSILS 254

Human   261 SWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKS 325
            ||||||.|.|||:|:|.||::||:||||..|..::|:|.|.|..||...:|:|:|||:|.|:||:
Mouse   255 SWVLLMDYAGNASAVFLLPEDGKMQHLEQTLNKELISKILLNRRRRLVQIHIPRLSISGDYNLKT 319

Human   326 VLGQLGITKVFSNGADLSGVTEE-APLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVK 389
            ::..||||::|:|||||||:||| ||||||||||||||||||.|||||.|...||:|||:||.::
Mouse   320 LMSPLGITRIFNNGADLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVFEAVPMSMPPILR 384

Human   390 FNKPFVFLMIEQNTKSPLFMGKVVNPTQK 418
            |:.||:|::.|::|:||:|:||||:||.|
Mouse   385 FDHPFLFIIFEEHTQSPIFVGKVVDPTHK 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	240/367 (65%)
		RCL	368..392		14/23 (61%)
Serpina1b	NP_033270.3	serpinA1_A1AT	44..412	CDD:381012	240/367 (65%)
		RCL	368..387		9/18 (50%)