DRSC/TRiP Functional Genomics Resources

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Protein Alignment SERPINA1 and Serpina1a

DIOPT Version :10

Sequence 1:NP_000286.3 Gene:SERPINA1 / 5265 HGNCID:8941 Length:418 Species:Homo sapiens
Sequence 2:NP_001239498.1 Gene:Serpina1a / 20700 MGIID:891971 Length:436 Species:Mus musculus


Alignment Length:190 Identity:41/190 - (21%)
Similarity:70/190 - (36%) Gaps:51/190 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    11 ETAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNE--TADTVLKKLDEQYQKYKFMELNLAQKKRRL 73
            ||.|....:|       |.:|..|..:......  ::::....::|:.:|.|..||.  .|:.::
Mouse   382 ETGAPRNSKL-------VSMESKDKLIMASNGSLVSSNSADNDVNEEQKKEKIAELK--DKQEKI 437

Human    74 KGQIPEIKQTLEILKYMQKKKESTNSMETRFLLADNLYCKASVPPT--DKVCLWLGANVMLEYDI 136
            | ||..:|:. |:.|...::.|.|..:...|.||     ....|||  .:|......:.:..||.
Mouse   438 K-QILALKEE-ELKKMCLREAELTGVLPKEFPLA-----SGEKPPTIRRRVGTAFKLDDLFPYDA 495

Human   137 DEAQALLE-------------------------------KNLSTATKNLDSLEEDLDFLR 165
            |.....||                               :||..|||.|.::|.:::..|
Mouse   496 DPCLRNLESCFALQKKIVEAARKLAHENELGKTVKKKRRRNLLDATKKLQAIENEINDYR 555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SERPINA1NP_000286.3 serpinA1_A1AT 50..417 CDD:381012 34/149 (23%)
RCL 368..392
Serpina1aNP_001239498.1 serpinA1_A1AT 67..435 CDD:381012 13/61 (21%)
Blue background indicates that the domain is not in the aligned region.

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