Protein Alignment SERPINA1 and srp-8

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001309497.1
• Gene: srp-8 / 191960
• WormBaseID: WBGene00005649
• Length: 372
• Species: Caenorhabditis elegans
• Alignment Length: 382
• Identity: 95/382 - (24%)
• Similarity: 170/382 - (44%)
• Gaps: 24/382 - (6%)

Human    38 SHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILE 102
            |:.|:.|...:|   :.||||..|..|   |.:|.:..|||::|:.|...|....:.:|..:|.:
 Worm     2 SNDDKLHEFLSK---SEAEFALKLLHQ---QDHSQSFVFSPIAISLALYSLYEAARGETRSQIHD 60

Human   103 GLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAF 167
            .|..|.|: .|...|  |..:...|:......|:...|.:....|:|.....|:.||.||:.|..
 Worm    61 CLFKNATD-GEMVTH--FSNVSTALSAMKKDPQVKICNHIICRNGIKTESLCLDKVKLLYNCEVS 122

Human   168 TVNFGDTEEAKKQINDYVEKGTQGKI--VDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEE 230
            :.:..:.:|..|.||..:.:.|.|.|  ::....:|:|.|...::...|:.:|:..|....|.::
 Worm   123 SHDLDNEKETIKTINKLIRENTDGHIKKINTKISIDKDQVVVFLSAACFEAQWQNKFHKLSTSKK 187

Human   231 DFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAI-FFLPDE--GKLQHLENELT 292
            :|.....:...:..:...|. |.::|:.....||.:.|..::..: .|||.|  |..:.|:. |.
 Worm   188 EFFCTANSHRNIKFLHATGA-NRKYCENDKFQVLSLPYTDSSFEMTIFLPKEQFGLAEALKT-LG 250

Human   293 HDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAV 357
            ...|.:...|......::.:|........||.|.|..:||||:.:..|.:....|.  :.:|:.:
 Worm   251 TSTIQELKSNVSNYLVNVQIPIWRNETEIDLNSTLQAIGITKILNESAYIGNFAEN--VHISEFI 313

Human   358 HKAVLTIDEKGTE-AAGAMFLEAIPMSIPPEVK---FNKPFVFLMIEQNTKSPLFMG 410
            |||::.::|.||. |.....:.........|::   .:.||::.:..:|  |.||||
 Worm   314 HKAIIEVNENGTSPATNTKVITKRWREETGEIRDFIADHPFLYTIHYKN--SILFMG 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	91/370 (25%)
		RCL	368..392		4/27 (15%)
srp-8	NP_001309497.1	serpinL_nematode	14..370	CDD:381047	91/367 (25%)