Protein Alignment SERPINA1 and serpina1

DIOPT Version :10

• Sequence 1: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Sequence 2: XP_004917137.1
• Gene: serpina1 / 100145012
• XenbaseID: XB-GENE-5804366
• Length: 485
• Species: Xenopus tropicalis
• Alignment Length: 434
• Identity: 213/434 - (49%)
• Similarity: 275/434 - (63%)
• Gaps: 31/434 - (7%)

Human     9 ILLLAGLCCLVPVSLAEDPQGDAAQKTDTSH-------HDQDH--------------------PT 46
            |:.||.||    ..:..|..|......|..|       ||.||                    ..
 Frog    54 IVSLALLC----AGVLADHDGQTKHGKDHDHNGHDHGDHDHDHHHHGKGKHHDHKHHHHAGEDMA 114

Human    47 FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEI 111
            .:||.|:.::|||.|:||:.....|.|||||||||:||.||||||.:|||.::|:||||||.|:|
 Frog   115 CHKIAPSNSQFAFKLFRQVVADHPSENIFFSPVSISTALAMLSLGARADTLNQIIEGLNFNNTKI 179

Human   112 PEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEE 176
            .|.:||.|||.||..||.||.:|||.:||.||:...:||:.:|::||||.|.||||:.:|.:.||
 Frog   180 TEEEIHNGFQHLLHMLNDPDRELQLNSGNALFIDNNVKLIQQFIDDVKKYYESEAFSTDFNNAEE 244

Human   177 AKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVK 241
            ||||||.||||.|.||||||:..:|::.|..|:|||||:||||:|||.|.|::..||||:.|.|.
 Frog   245 AKKQINSYVEKQTHGKIVDLLSSVDKNAVLYLINYIFFRGKWEKPFEEKFTQDGIFHVDENTNVT 309

Human   242 VPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRR 306
            ||||:|.||:|:...:||...|:.:.|.|||||:|.|||||||:.:|..|....|..:.:....:
 Frog   310 VPMMRRNGMYNVAFDEKLGCTVVQIPYKGNATALFILPDEGKLRQVEEALEKSTIMSWKKQFRYQ 374

Human   307 SASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEA 371
            |..|.:||.||..|.||...|.:.|:|.|||..|||||:.|..|||:|||||||.|::||.||||
 Frog   375 SIELTIPKFSIMATLDLIEELKKFGVTDVFSQNADLSGIVEGTPLKVSKAVHKAGLSVDETGTEA 439

Human   372 AGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
            |.|...|.:||.|||.:.||:.||.::.:...||.||:.|||||
 Frog   440 AAATAFEIMPMMIPPHILFNRAFVVIIYDPIPKSILFVAKVVNP 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	199/366 (54%)
		RCL	368..392		13/23 (57%)
serpina1	XP_004917137.1	serpin	115..484	CDD:476815	200/369 (54%)