Protein Alignment PHKG2 and CMK2

DIOPT Version :9

• Sequence 1: NP_000285.1
• Gene: PHKG2 / 5261
• HGNCID: 8931
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_014626.1
• Gene: CMK2 / 854144
• SGDID: S000005376
• Length: 447
• Species: Saccharomyces cerevisiae
• Alignment Length: 422
• Identity: 125/422 - (29%)
• Similarity: 199/422 - (47%)
• Gaps: 85/422 - (20%)

Human    30 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLI 94
            :|.|...|||:....:|..:.|:||:...|.:.:..||:.:.|    |..||:::: ||:|::..
Yeast    53 LGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYE----ELSILQKLS-HPNIVSFK 112

Human    95 DSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENI 159
            |.:||....::|..|...|||||.:..:...:|.:...|:..:|.||.::|:.|:|||||||||:
Yeast   113 DWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENV 177

Human   160 LLDD---NMQIRLSDFGFSCHLEPGEKL-RELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220
            |..|   |..:.::|||.:..|:..|.| .:..|:.||:|||:|      |..|:||..|:|:.|
Yeast   178 LYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVL------TQDGHGKPCDIWSIG 236

Human   221 VILFTLLAGSPPFWHRRQILMLRMIMEGQYQ----------FSSPEWDDRSSTVKDLISRLLQVD 275
            ||.:|||.|..||        :...:||..:          |..|.||:.|..||..|.:.|:::
Yeast   237 VITYTLLCGYSPF--------IAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLN 293

Human   276 PEARLTAEQALQHPFF--ERCEGSQPWNLTP--------RQRFRVAVWTVLAAGRV-------AL 323
            |..|.||.:.|..|:.  :|.|.|   |:.|        |::.|.|:..|....|:       :|
Yeast   294 PADRPTATELLDDPWITSKRVETS---NILPDVKKGFSLRKKLRDAIEIVKLNNRIKRLRNMYSL 355

Human   324 STHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKG----EQQNR-------------- 370
            .......:.:|:|  :...|..|.|.:|:  .||...  |||    |:|.:
Yeast   356 GDDGDNDIEENSL--NESLLDGVTHSLDD--LRLQSQ--KKGGELTEEQMKLKSALTKDAFVQIV 414

Human   371 --AALFQHRPPGPFPIMGPEEEGDSAAITEDE 400
              |...:|:      ::..|||.||.....|:
Yeast   415 KAATKNKHK------VLAGEEEDDSKKTLHDD 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKG2	NP_000285.1	STKc_PhKG2	13..291	CDD:271083	93/274 (34%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		5/30 (17%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370		10/27 (37%)
CMK2	NP_014626.1	STKc_CAMK	46..308	CDD:270687	92/273 (34%)
		S_TKc	47..309	CDD:214567	93/274 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010