Protein Alignment PHKG2 and MAPk-Ak2

DIOPT Version :10

• Sequence 1: NP_000285.1
• Gene: PHKG2 / 5261
• HGNCID: 8931
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Alignment Length: 329
• Identity: 102/329 - (31%)
• Similarity: 161/329 - (48%)
• Gaps: 46/329 - (13%)

Human    29 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITL 93
            |:|.|::..|.:|.||.|...:|:|:: :.:||            .|||..:..:|:|..:|:.:
  Fly    25 VLGYGINGKVVQCTHRRTQQNYALKVL-LDSER------------ARREVDLHWRVSGCRYIVNI 76

Human    94 IDSYESS----SFMFLVFDLMRKGELFDYLTEKV--ALSEKETRSIMRSLLEAVSFLHANNIVHR 152
            ||.||::    ..:.:|.:.|..||||..:.:|.  |.:|:|...||..:..||.:||:.:|.||
  Fly    77 IDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHR 141

Human   153 DLKPENIL---LDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEV 214
            ||||||:|   ...|..::|:||||:........|:..|.||.|:|||:|....      |.|..
  Fly   142 DLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEK------YDKSC 200

Human   215 DLWACGVILFTLLAGSPPFWHRRQIL----MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVD 275
            |:|:.||:::.::.|.|||:....:.    |...|..|||.|..|||.:.|...||||..:|.||
  Fly   201 DIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVD 265

Human   276 PEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDP 340
            |..||..:..:.:.:..:      :|..|:        |.|..||:........|..:..:.|..
  Fly   266 PSKRLRIQDVISNKWIAQ------YNAVPQ--------TPLCTGRMLKEAEETWPEVQEEMTRSL 316

Human   341 YALR 344
            ..:|
  Fly   317 ATMR 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKG2	NP_000285.1	STKc_PhKG2	13..291	CDD:271083	93/274 (34%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		4/23 (17%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	93/273 (34%)