Protein Alignment PHKG2 and PhKgamma

DIOPT Version :10

• Sequence 1: NP_000285.1
• Gene: PHKG2 / 5261
• HGNCID: 8931
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 213/540 - (39%)
• Similarity: 274/540 - (50%)
• Gaps: 169/540 - (31%)

Human     8 EDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPE-QLEEVR 71
            :|.|||..|||.||.||:||:::|||:||.||||:.:.||.|||.||:::.|...|.| ....:.
  Fly     7 DDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHML 71

Human    72 EATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136
            ||||:|..|||||.|||:||.|.|.:||.:|:||||:|..|||||||||..|.||||:||:|||.
  Fly    72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQ 136

Human   137 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKC 201
            :.|.|.::||.:||||||||||||||:|..::::||||:..|:.||||..|||||||||||.|||
  Fly   137 IFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKC 201

Human   202 SMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKD 266
            :|.|..|||.:|||:||||||:||||.|.||||||:|::|||.||||:|.|:||||.|.|...||
  Fly   202 NMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKD 266

Human   267 LISRLLQVDPEARLTAEQALQHPFFER-------------------------------------- 293
            ||.:.|.|||..|:|.::.|:||||.:
  Fly   267 LIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSYRFGQLN 331

Human   294 --CEGS----------------------------------------------------------- 297
              |.|:
  Fly   332 SSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSAL 396

Human   298 -----------------QPW--------------------------------------------- 300
                             ||.
  Fly   397 ASASSHKTLTAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPPT 461

Human   301 -------NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLY 358
                   ....|::|:.|:..:.|..|:........||.....:||||.::.:|.:||.||||:|
  Fly   462 VQLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPLHVEEAIRDPYRVKVLRKVIDGCAFRVY 526

Human   359 GHWVKKGEQQNRAALFQHRP 378
            ||||||||.|||||||::.|
  Fly   527 GHWVKKGEGQNRAALFENTP 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKG2	NP_000285.1	STKc_PhKG2	13..291	CDD:271083	169/278 (61%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		4/23 (17%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370		17/23 (74%)
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	165/271 (61%)