DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHKG1 and phkg1a

DIOPT Version :9

Sequence 1:	XP_016867813.1	Gene:	PHKG1 / 5260	HGNCID:	8930	Length:	432	Species:	Homo sapiens
Sequence 2:	NP_001071080.1	Gene:	phkg1a / 565379	ZFINID:	ZDB-GENE-061103-385	Length:	394	Species:	Danio rerio

Alignment Length:	430	Identity:	286/430 - (66%)
Similarity:	333/430 - (77%)	Gaps:	45/430 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVR 65
            ||:::.:||...|||||:.|:|||||||||||||||||||.|:|||||||||:|.....:.||:.
Zfish     1 MTKEDEIPDWAGAQDFYQKYDPKEILGRGVSSVVRRCIHKRTTQEYAVKVIDITPSDKMNTEEIE 65

Human    66 ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKI 130
            |:|.||:||:|||:||.|..|||||||.:||..||||||||||:|||||||||||||||||||||
Zfish    66 EIRNATIKEIDILKKVCGQENIIQLKDCFETKAFFFLVFDLMKKGELFDYLTEKVTLSEKETRKI 130

Human   131 MRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLRVETGFHHVGQAGL 195
            ||:||||:..||..|||||||||||||||||||||||||||:.|:.||::|
Zfish   131 MRSLLEVVQFLHSQNIVHRDLKPENILLDDNMNIKLTDFGFAVQIAPGQKL-------------- 181

Human   196 ELLTLRSARLGLPKCCDYRREPPCPAGLGISSEVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWS 260
                                           :||||||.|||||||||||:..|.|||..||:||
Zfish   182 -------------------------------NEVCGTPGYLAPEIIECSMDPHHQGYGAAVDLWS 215

Human   261 TGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAE 325
            .||||:|||||||||||||||||||||::|||||.||||||.|||||||:|:.|||.|:.|:||.
Zfish   216 AGVIMFTLLAGSPPFWHRKQMLMLRMILAGNYQFTSPEWDDRSDTVKDLISKMLVVNPEKRFTAT 280

Human   326 EALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRR 390
            :||.|||||||:|.|||||||..|||||.:||||::|||..|||.||||:|::..||||::|:|:
Zfish   281 DALNHPFFQQYVVAEVRHFSPYRKFKVICMTVLATMRIYCNYRRAKPVTKEVIKSDPYAVKPIRK 345

Human   391 LIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEE 430
            ||||.||:||||||||||.|||||||||:|||:|||||.|
Zfish   346 LIDACAFKIYGHWVKKGQTQNRAALFENSPKAILLSLAAE 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHKG1	XP_016867813.1	None
phkg1a	NP_001071080.1	STKc_PhKG1	16..291	CDD:271084	209/319 (66%)
phkg1a	NP_001071080.1	S_TKc	20..288	CDD:214567	204/312 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339468
Domainoid	1	1.000	432	1.000	Domainoid score	I3909
eggNOG	1	0.900	-	-		E1_KOG0599
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68508
Inparanoid	1	1.050	601	1.000	Inparanoid score	I5253
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48604
OrthoDB	1	1.010	-	-		D225045at7742
OrthoFinder	1	1.000	-	-		FOG0002585
OrthoInspector	1	1.000	-	-		otm28582
orthoMCL	1	0.900	-	-		OOG6_105085
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4277
SonicParanoid	1	1.000	-	-		X1942
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300