Protein Alignment PHKA2 and phka2

DIOPT Version :10

• Sequence 1: NP_001427734.1
• Gene: PHKA2 / 5256
• HGNCID: 8926
• Length: 1243
• Species: Homo sapiens
• Sequence 2: XP_021335546.1
• Gene: phka2 / 556199
• ZFINID: ZDB-GENE-130422-1
• Length: 1224
• Species: Danio rerio
• Alignment Length: 1249
• Identity: 915/1249 - (73%)
• Similarity: 1045/1249 - (83%)
• Gaps: 31/1249 - (2%)

Human     1 MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHEQKDAWVRDNIYSILAVWGLGMAYRKNA 65
            |||||||||||||:||||.:||||:||||||||.||.:|||||||||:|||||||||||||||||
Zfish     1 MRSRSNSGVRLDGFARLVHETILCHQNPVTGLLPASEQQKDAWVRDNVYSILAVWGLGMAYRKNA 65

Human    66 DRDEDKAKAYELEQNVVKLMRGLLQCMMRQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVGDDQW 130
            ||||||||||||||:|||||:||||||||||.|||||||||||||.|||||:|.||.||||||||
Zfish    66 DRDEDKAKAYELEQSVVKLMQGLLQCMMRQVEKVEKFKHTQSTKDCLHAKYHTPTCATVVGDDQW 130

Human   131 GHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195
            ||||||||||:||.|||||||||.||..|||||||||||||||||||||||||||||||||||||
Zfish   131 GHLQVDATSLYLLTLAQMTASGLHIISNLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195

Human   196 ELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLL 260
            |||.||||||||||||||||||||||||.||||||||||||||||||.|||||||||||||||||
Zfish   196 ELNGSSVGMAKAALEAIDELDLFGAHGGPKSVIHVLPDEVEHCQSILCSMLPRASTSKEIDAGLL 260

Human   261 SIISFPAFAVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKLFENIE 325
            |:||||||||||.:|||:||.|||:|||||||||||:||||:||:|||.||||||||||||||||
Zfish   261 SVISFPAFAVEDADLVNITKAEIITKLQGRYGCCRFIRDGYRTPKEDPTRLHYDPAELKLFENIE 325

Human   326 CEWPVFWTYFIIDGVFSGDAVQVQEYREALEGILIRGKNGIRLVPELYAVPPNKVDEEYKNPHTV 390
            |||||||||.|:||:|:.|..||:||||||:|:|||||:||||||||||||.:||:|||:|||:|
Zfish   326 CEWPVFWTYLILDGIFNADHEQVEEYREALDGVLIRGKHGIRLVPELYAVPADKVEEEYRNPHSV 390

Human   391 DRVPMGKVPHLWGQSLYILSSLLAEGFLAAGEIDPLNRRFSTSVKPDVVVQVTVLAENNHIKDLL 455
            :||..|::||:||||||||.|||.|||||.|||||||||||...||||||||:|:||:..|:.||
Zfish   391 ERVAFGQLPHMWGQSLYILGSLLTEGFLAPGEIDPLNRRFSKEFKPDVVVQVSVVAESVQIQQLL 455

Human   456 RKHGVNVQSIADIHPIQVQPGRILSHIYAKLGRNKNMNLSGRPYRHIGVLGTSKLYVIRNQIFTF 520
            |.||:.||:::|:.||:|.|.|||||||.|||..|.:|||||||||||||||||.|.|||..:||
Zfish   456 RDHGIEVQTVSDVSPIRVMPARILSHIYVKLGNCKKLNLSGRPYRHIGVLGTSKFYEIRNGTYTF 520

Human   521 TPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWRMTGRPTLTFPISRTMLTNDGSDIHSAVLST 585
            ||||.|||||||||||:|||||||.|||||.:||||||||||||||:::||..||..|...:|||
Zfish   521 TPQFIDQHHFYLALDNQMIVEMLRTELAYLSSCWRMTGRPTLTFPITQSMLVEDGDSIDPCILST 585

Human   586 IRKLEDGYFGGARVKLGNLSEFLTTSFYTYLTFLDPDCDEKLFDNASEGTFSPDSDSDLVGYLED 650
            :|||:|||||||||::.|||.||||||:|.|:|||.|.:|.|.:...|    .|.::...|
Zfish   586 LRKLQDGYFGGARVQMANLSSFLTTSFHTQLSFLDGDSEEDLLEEEEE----EDEEASAGG---- 642

Human   651 TCNQESQDELDHYINHLLQSTSLRSYLPPLCKNTEDRHVFSAIHSTRDILSVMAKAKGLEVPFVP 715
                 |.|..|.|:..||.||:.:.:|||:.:.  ..|||||.|:||||||.||:.:|..:|...
Zfish   643 -----SGDMFDQYLTDLLHSTTTKCHLPPIQRG--QHHVFSAEHTTRDILSFMAQVQGHNMPKPS 700

Human   716 MTLP-TKVLSAHRKSLNLVDSPQPLLE---KVPESDFQWPRDDHGDVDCEKLVEQLKDCSNLQDQ 776
            |.|| ..::|.|||||||:|.||....   |....|...|||.||:.|...||:|||.|..||||
Zfish   701 MYLPVAPIMSKHRKSLNLLDVPQHKASPQTKADNVDLHLPRDSHGNTDFVHLVDQLKHCPTLQDQ 765

Human   777 ADILYILYVIKGPSWDTNLSGQHGVTVQNLLGELYGKAGLNQEWGLIRYISGLLRKKVEVLAEAC 841
            |||||:||.:|||:|..:||||...||::||.|||.:||..:||||||||||:|:|:||||||||
Zfish   766 ADILYVLYAMKGPNWVVSLSGQGEATVRSLLEELYVRAGACKEWGLIRYISGILKKRVEVLAEAC 830

Human   842 TDLLSHQKQLTVGLPPEPREKIISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRAQP 906
            |||:||.||||||||||||||:|:.|||||||..|||||||||||||||||||:||||||||:||
Zfish   831 TDLISHHKQLTVGLPPEPREKVITVPLPPEELISLIYEASGQDISIAVLTQEIMVYLAMYVRSQP 895

Human   907 SLFVEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSGKEFGVERSVR 971
            |||.:|||||||||:|||||||||||:|||||||||||:||||||||||||||||||||||||:|
Zfish   896 SLFGDMLRLRIGLIMQVMATELARSLHCSGEEASESLMSLSPFDMKNLLHHILSGKEFGVERSMR 960

Human   972 PIHSSTSSPTISIHEVGHTGVTKTERSGINRLRSEMKQMTRRFSADEQFFSVGQAASSSAHSSKS 1036
            ||.||.:||.|||||:||||.|||||:||.:|::|:||:.     |.:..|:    .||:||..|
Zfish   961 PIQSSATSPAISIHELGHTGATKTERTGIRKLKTEIKQLD-----DSRPISI----YSSSHSISS 1016

Human  1037 AVTVPRDYCRSSTPSSPTG-TSSSDSGGHHIGWGERQGQWLRRRRLDGAINRVPVGFYQRVWKIL 1100
            .||.||. .|.|:||:|:| .|.:.:|..|:.|.||||||||||||||||||||:||||:|||||
Zfish  1017 NVTSPRS-TRCSSPSTPSGILSPTGTGDCHLQWEERQGQWLRRRRLDGAINRVPMGFYQKVWKIL 1080

Human  1101 QKCHGLSIDGYVLPSSTTREMTPHEIKFAVHVESVLNRVPQPEYRQLLVEAIMVLTLLSDTEMTS 1165
            ||||||||.|||||||||||||..|||||||||||||.|||||||||||||||||||::|.|:.|
Zfish  1081 QKCHGLSIAGYVLPSSTTREMTEGEIKFAVHVESVLNHVPQPEYRQLLVEAIMVLTLVADMEIPS 1145

Human  1166 IGGIIHVDQIVQMASQLFLQDQVSIGAMD-TLEKDQATGICHFFYDSAPSGAYGTMTYLTRAVAS 1229
            :|||||:|:||.||:.||.|||.|.||.: .||:|.|||||:|||||||||:|||||||::||.:
Zfish  1146 VGGIIHIDRIVHMANDLFQQDQRSSGANEYFLEQDPATGICNFFYDSAPSGSYGTMTYLSKAVVT 1210

Human  1230 YLQELLPNSGCQMQ 1243
            |:|:.||||.|.||
Zfish  1211 YVQDFLPNSSCLMQ 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKA2	NP_001427734.1	Calmodulin-binding. /evidence=ECO:0000255	807..837		20/29 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..998		19/25 (76%)
		Calmodulin-binding. /evidence=ECO:0000255	1067..1107		35/39 (90%)
phka2	XP_021335546.1	Glyco_hydro_15	8..>437	CDD:395586	367/428 (86%)
		Bac_rhamnosid6H	<790..908	CDD:481215	94/117 (80%)
		KPBB_C	919..>1141	CDD:437124	168/231 (73%)