Protein Alignment PHKA2 and CG7766

DIOPT Version :10

• Sequence 1: NP_001427734.1
• Gene: PHKA2 / 5256
• HGNCID: 8926
• Length: 1243
• Species: Homo sapiens
• Sequence 2: NP_001245588.1
• Gene: CG7766 / 31839
• FlyBaseID: FBgn0030087
• Length: 1358
• Species: Drosophila melanogaster
• Alignment Length: 1458
• Identity: 646/1458 - (44%)
• Similarity: 830/1458 - (56%)
• Gaps: 326/1458 - (22%)

Human     1 MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHEQKDAWVRDNIYSILAVWGLGMAYRKNA 65
            ||||||||||||.|.|:|.:.||.:|.|||||..||:....||:|||:|.|||||||.|||:|.|
  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIA 65

Human    66 DRDEDKAKAYELEQNVVKLMRGLLQCMMRQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVGDDQW 130
            |:|||:||.|||||:.||||||||..||.|..||||||.|||..|||||||::.....||.|::|
  Fly    66 DQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEW 130

Human   131 GHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195
            ||||:||.||:||.|||||||||:|:|:||||:||||||||||:||.:.|||:||||||||.|.|
  Fly   131 GHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEP 195

Human   196 ELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLL 260
            ||||||:|||||||||::|||||||.||..||||||.||...||::|.|||||.|.|||:|:|||
  Fly   196 ELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLL 260

Human   261 SIISFPAFAVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKLFENIE 325
            .:|.||||||:|..|::.||:.|:|:|||:|||.|||||||:||:|||:||:|:..||::|||||
  Fly   261 CVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIE 325

Human   326 CEWPVFWTYFIIDGVFSGDAVQVQEYREALEGILIRGKNGIRLVPELYAVPPNKVDEEYKNPHTV 390
            ||||:|:.|.|:...|..|...|:||...||.|::|.::||.||||.||||.:.|..||:.|.:.
  Fly   326 CEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQ 390

Human   391 DRVPMGKVPHLWGQSLYILSSLLAEGFLAAGEIDPLNRRFSTSVKPDVVVQVTVLAENNHIKDLL 455
            .|..:|:.|.||||||:||..||.|||||.||:||||||.....||||||||.::||:|.|:|.|
  Fly   391 VREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKL 455

Human   456 RKHGVNVQSIADIHPIQVQPGRILSHIYAKLGRNKNMNLSGRPYRHIGVLGTSKLYVIRNQIFTF 520
            .:|.::||:||::.||:|||.|:|||:|..||||:.:.||||..|.:|:|.|||||.::::||.|
  Fly   456 AEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAF 520

Human   521 TPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWR-MTGRPTLTFPISRTMLTNDGSDIHSAVLS 584
            |||..|...:|...|.:::.......||:|...|| |.||||:|...:..||..|  .|..|::.
  Fly   521 TPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYMLDQD--KIPLAMIQ 583

Human   585 TIRKLEDGYFGGARVKLGNLSEFLTTSFYTYLTFLDPDCDEKLFDNASEGTFSPDSDSDLVGYLE 649
            |:|||:.||..|.||.||:|.:||.||..|.|:||....|                     || .
  Fly   584 TMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFLGSTED---------------------GY-P 626

Human   650 DTCNQESQDELDHYINHLLQSTSLRS-------YLPP-------LCKNTEDRHVFSAIHSTRDIL 700
            |..:.:.|..||   .|||:|.|.||       .|.|       .||        .||..||.|
  Fly   627 DRLHPDVQTYLD---EHLLRSFSNRSTMNLRGGQLRPRTLRRRMSCK--------GAIKKTRSI- 679

Human   701 SVMAKAKGLEVPFVPMT-------LPTKVLSAHRKSLNLVDSPQPLLEKVPES-----------D 747
            :|.:...|:|.| .|:|       :|...|.|:::|...|.:..|  |:.|.|           :
  Fly   680 NVDSDNLGMEGP-SPLTERRLSSIVPPPWLQANKQSHVSVFATTP--EEGPTSSPLSLGNDLIRE 741

Human   748 FQWPRDDH----------------------------------GDVDCEKLVEQLKDCSNLQDQAD 778
            ..:|.|.|                                  .|.:.|:|:..|::..||::|.|
  Fly   742 NIYPVDPHHSRSAIDRRSEFVRQQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGD 806

Human   779 ILYILYVIKGPSWDT-------------------------------------------------- 793
            ||..|...:|..::|
  Fly   807 ILQYLVDTQGLDFNTAGLGFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDG 871

Human   794 ---------------------------------------------------------NLSGQHG- 800
                                                                     |:|..:.
  Fly   872 AKKSPTIVLPTVIIDAATIPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNM 936

Human   801 ---------------------VTVQNLLGELYGKAGLNQEWGLIRYISGLLRKKVEVLAEACTDL 844
                                 |||::||..||.||...:.|||:|:.:|:|.|:||.||:|.|||
  Fly   937 SPHENNHDSSQSEGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDL 1001

Human   845 LSHQKQLTVGLPPEPREKIISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLF 909
            |..|||:|||:||. .|..|:||||..||.:||::|.|.|.|.|:||||::|||||::|.:|.||
  Fly  1002 LVRQKQVTVGMPPN-NEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLF 1065

Human   910 VEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSGKEFGVERSVRPIH 974
            .||||||:||||||||.||:|:|||.||.|||.|:|||||:|||||:||||||||
  Fly  1066 HEMLRLRVGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEF---------- 1120

Human   975 SSTSSPTISIHEVGHTGVTKTERSGINRLRSEMKQMTRRFSADEQFFSVGQAASSSAHSSKSAVT 1039
                                                               |.||.|..:.|.|:
  Fly  1121 ---------------------------------------------------AVSSVARGNLSIVS 1134

Human  1040 VPRDYCRSSTPSSPTGTSSSDSGGHH---IGWGERQGQWLRRRRLDGAINRVPVGFYQRVWKILQ 1101
                 |:||..|..:.....|..|..   ....:||||||||||||||:||||..||.|||.:|:
  Fly  1135 -----CKSSRVSKKSQIGLGDPEGEDALIATIDDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLE 1194

Human  1102 KCHGLSIDGYVLPSSTTREMTPHEIKFAVHVESVLNRVPQPEYRQLLVEAIMVLTLLSDTEMT-S 1165
            ||.||:|:|.||..|.|:||||.|:|||:.||:.||::||||||||:|||:|||||:::..|. |
  Fly  1195 KCQGLAIEGRVLQQSLTQEMTPGELKFALEVETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPS 1259

Human  1166 IGGIIHVDQIVQMASQLFLQDQVSIGAMDTL---------EKDQATG----------ICHFFYDS 1211
            :||:|:|:.:|..|:||||:||..:....||         |:.||..          ||...|||
  Fly  1260 LGGVIYVEHLVHKANQLFLEDQRKVQGDATLCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDS 1324

Human  1212 APSGAYGTMTYLTRAVASYLQELLPNSG 1239
            ||||:||||||::||||..| :.:|..|
  Fly  1325 APSGSYGTMTYMSRAVALVL-DCVPKHG 1351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKA2	NP_001427734.1	Calmodulin-binding. /evidence=ECO:0000255	807..837		14/29 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..998		0/25 (0%)
		Calmodulin-binding. /evidence=ECO:0000255	1067..1107		27/39 (69%)
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:395586	276/430 (64%)
		Bac_rhamnosid6H	<959..1075	CDD:481215	66/116 (57%)
		KPBB_C	1086..>1260	CDD:437124	103/239 (43%)