Protein Alignment PHKA2 and C14B9.8

DIOPT Version :10

• Sequence 1: NP_001427734.1
• Gene: PHKA2 / 5256
• HGNCID: 8926
• Length: 1243
• Species: Homo sapiens
• Sequence 2: NP_001348739.1
• Gene: C14B9.8 / 176149
• WormBaseID: WBGene00015754
• Length: 1232
• Species: Caenorhabditis elegans
• Alignment Length: 1306
• Identity: 530/1306 - (40%)
• Similarity: 742/1306 - (56%)
• Gaps: 158/1306 - (12%)

Human     1 MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHEQKD----AWVRDNIYSILAVWGLGMAY 61
            |||||.||||||....:|:|||..:|||:|.|.:   .|||    ||||||:|...|:|.|..||
 Worm     1 MRSRSGSGVRLDRILFMVEQTICSHQNPITALFA---NQKDFPGHAWVRDNVYIAQALWALYRAY 62

Human    62 RKNADRDEDKAKAYELEQNVVKLMRGLLQCMMRQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVG 126
            .|.||.|||..||.||....||:|:.:|:|:|||..|||.||..|...|:||:|:...|.|||.|
 Worm    63 MKCADFDEDLTKAKELGFTCVKMMQSILECLMRQAEKVELFKKYQRPLDALHSKFAVGTKGTVCG 127

Human   127 DDQWGHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTN 191
            |..|||||:||.||:||.|||:|||||:::...||||||||||:|||..|:..|||:||||||||
 Worm   128 DADWGHLQMDAISLYLLTLAQITASGLQVVRNFDEVAFIQNLVYYIETGYRTPDYGVWERGDKTN 192

Human   192 QGIPELNASSVGMAKAALEAIDEL-DLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEI 255
            |||.||||||:||.||||:|:::: ||| ..|.|.||:||||||:|.|.::|.|||||.|.|||.
 Worm   193 QGIRELNASSIGMVKAALQALNDVGDLF-VDGSRGSVVHVLPDEIEQCSAVLSSMLPRESFSKET 256

Human   256 DAGLLSIISFPAFAVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKL 320
            ||.||.|||:|||.|||..||:.|:..|..:|.|:|||.||:||||||..||.:||:|:.:||:.
 Worm   257 DAALLGIISYPAFCVEDPELVSQTRETITQRLLGKYGCRRFMRDGYKTVLEDASRLYYNKSELQQ 321

Human   321 FENIECEWPVFWTYFIIDGVFSGDAVQVQEYREALEGILIRGKNGIRLVPELYAVPPNKVDEEYK 385
            ||:||||||:|..|.|:|.::|.|...|:.|...||.:|:....|.|||||||.|....|..|..
 Worm   322 FEDIECEWPIFLCYLILDAMYSKDDDAVEAYWRQLESVLVLSDKGFRLVPELYVVLKEHVSAEKA 386

Human   386 NPHTVDRVPMGKVPHLWGQSLYILSSLLAEGFLAAGEIDPLNRRFSTSVK-PDVVVQVTVLAENN 449
            :|.|.||||.|..|.||.||||::..||.||||...|:|||:||.|...| |...||||||||:.
 Worm   387 HPGTQDRVPGGATPFLWAQSLYVIICLLYEGFLLPAELDPLSRRLSVYEKRPPCEVQVTVLAESL 451

Human   450 HIKDLLRKHGVNVQSIADIHPI-QVQPGRILSHIYAKLGRNKNMNLSGRPY-RHIGVLGTSKLYV 512
            .::..||.|.::||.:.:|.|: .:.|...|..:.||:|.:|.:||||||. |.||:|.||:||.
 Worm   452 DVQRELRAHDIHVQCVDEIDPVFTILPASALGQLLAKIGESKKLNLSGRPLDRPIGLLSTSRLYQ 516

Human   513 IRNQIFTFTPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWR---MTGRPTLTFPISRTMLTND 574
            |.|:...|||||.|....:|..|..::.:....||.|:...|.   ::|||.:...|::.||:.:
 Worm   517 IGNKFVIFTPQFMDSRRSHLMYDIRILTDEWSSELQYIYASWNSVSISGRPLVVLVITQGMLSTE 581

Human   575 G----SDIH------SAVLSTIRKLEDGYFGGA---RVKLGNLSEFLTTSFYTYLTFLDPDCDEK 626
            |    |:||      |.|:..|:|:..||..||   ||.:.:||:|..|:..:.:.|.|...::.
 Worm   582 GLSHFSNIHLNRHMKSTVIGAIKKINTGYLSGASVCRVVMKDLSDFFRTTAVSKMEFRDKSAEDT 646

Human   627 LFDNASEGTFSPDSDSDLVGYLEDTCNQESQDELDHYINHLLQSTSLRSYLPPLCKNTEDRHVFS 691
            |...|:|..       ......||.  .|::...|..|.......:||.     .::.:||..::
 Worm   647 LRSVAAEKV-------QFTLLTEDA--TEAKRSSDEKITTPRGPRTLRR-----GESVKDRSAYT 697

Human   692 AIHST----RDI-------------LSVMAKAKGLE--------VPFVPMTLPTKVLSAHRKSLN 731
            |:|..    |.|             |:..::.:.|:        .|  |...|..::..|...
 Worm   698 AVHKASMRHRSIALDSNDADLMKLRLAYKSRPRDLQDMDSTYQSPP--PTQTPLGLVKEHSSG-- 758

Human   732 LVDSPQPLLE---KVPESDFQWPRDDHGDVDCEKL----VEQLKDCSN----LQDQADILYILYV 785
              :..|.||:   :..|::     ..|.|:..|::    .:.|.|..|    |::|..|::.|::
 Worm   759 --ELRQQLLKTTRRGAENE-----TTHRDLTAEQMNEMKADDLLDLVNETTVLEEQISIVHCLWM 816

Human   786 IKGPSWDTNLSGQHGVTVQNLLGELYGKAGLNQEWGLIRYISGLLRKKVEVLAEACTDLLSHQKQ 850
            ..||.:||.|..|| :||:.|:.|::.||...:||.|:|..:|||:|::|.|::|.|.||..|||
 Worm   817 KFGPDYDTELGCQH-ITVRMLMEEVHTKACEAREWALVRLTAGLLKKQLEELSKAVTHLLVRQKQ 880

Human   851 LTVGLPPEPREKIISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFVEMLRL 915
            :|||:..: :|::|:.|...|||.|::..|.|.|.:...|.|||:|||...||.:|.||:||.||
 Worm   881 ITVGIASK-KEEVITCPKTNEELEKIMNRAYGDDANSFTLAQEIIVYLGSLVRTEPKLFLEMFRL 944

Human   916 RIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSGK---EFGVERSVRPIHSST 977
            ||||||||:|:||:|..|.||.||:|:|:.:|||::|:::..:|||:   |:..:
 Worm   945 RIGLIIQVLASELSRLRNISGAEAAETLLTVSPFELKSMIFSLLSGRLLEEYAED---------- 999

Human   978 SSPTISIHEVGHTGVTKTERSGINRLRSEMKQMTRRFSADEQFFSVGQAASSSAHSSKSAVTVPR 1042
                 .||   ::...:..|:||...|   :|:..|.|..:...|||            .:.:|:
 Worm  1000 -----GIH---YSDTIRETRTGIGSFR---RQIEERKSLRKSTRSVG------------GLEIPK 1041

Human  1043 DYCRSSTPSSPTGTSSSDSGGHHIGWGERQGQWLRRRRLDGAINRVPVGFYQRVWKILQKC-HGL 1106
            :         ......:|......      |.|||.||:|||:||||.|||..:|..:.|. ||:
 Worm  1042 E---------EDEDEEADEDDFQF------GIWLRHRRIDGALNRVPNGFYAILWDTVHKMPHGV 1091

Human  1107 SIDGYVLPSSTTREMTPHEIKFAVHVESVLNRVPQPEYRQLLVEAIMVLTLLSDTEMTSIGGI-- 1169
            .|:..||....|:|||..|||||:..|..|||:.:||||:|:||.:.:|..|....:.....|
 Worm  1092 KINDTVLHWGLTQEMTRKEIKFALESEEALNRIAEPEYRELVVETLWLLGRLEKLVLLEQPNIPR 1156

Human  1170 ---IHVDQIVQMASQLFLQDQVSIGAM----------DTLEKDQATGICHFFYDSAPSGAYGTMT 1221
               :.||.|:.:|:|:|:.....:..:          :....|.|..||..||||||:|.|||..
 Worm  1157 DRPLDVDHILHVANQIFVDHNKHLETIVMECCASSNPNNTRCDGARNICKHFYDSAPAGEYGTSH 1221

Human  1222 YLTRAV 1227
            |:.||:
 Worm  1222 YIIRAL 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKA2	NP_001427734.1	Calmodulin-binding. /evidence=ECO:0000255	807..837		12/29 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..998		2/25 (8%)
		Calmodulin-binding. /evidence=ECO:0000255	1067..1107		20/40 (50%)
C14B9.8	NP_001348739.1	Bac_rhamnosid6H	8..>434	CDD:481215	242/429 (56%)
		Bac_rhamnosid6H	<832..948	CDD:481215	54/116 (47%)
		KPBB_C	959..>1137	CDD:437124	73/225 (32%)