Protein Alignment PHKA2 and phka2

DIOPT Version :10

• Sequence 1: NP_001427734.1
• Gene: PHKA2 / 5256
• HGNCID: 8926
• Length: 1243
• Species: Homo sapiens
• Sequence 2: XP_012812949.2
• Gene: phka2 / 100498261
• XenbaseID: XB-GENE-994491
• Length: 1240
• Species: Xenopus tropicalis
• Alignment Length: 1251
• Identity: 973/1251 - (77%)
• Similarity: 1089/1251 - (87%)
• Gaps: 19/1251 - (1%)

Human     1 MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHEQKDAWVRDNIYSILAVWGLGMAYRKNA 65
            |||||||||||||||||:||||||:||||||||.||.||||||||||:|||||||||||||||||
 Frog     1 MRSRSNSGVRLDGYARLIQQTILCHQNPVTGLLPASKEQKDAWVRDNVYSILAVWGLGMAYRKNA 65

Human    66 DRDEDKAKAYELEQNVVKLMRGLLQCMMRQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVGDDQW 130
            ||||||||||||||:|||||||:|.||:|||.|||||||||||||.||||||||||.|:||||||
 Frog    66 DRDEDKAKAYELEQSVVKLMRGILHCMIRQVDKVEKFKHTQSTKDCLHAKYNTATCSTIVGDDQW 130

Human   131 GHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195
            |||||||||||||.||||||:||||:|||:|||||||||||||||||||||||||||||||||||
 Frog   131 GHLQVDATSLFLLCLAQMTAAGLRIVFTLNEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195

Human   196 ELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLL 260
            ||||||||||||||||||||||||||||.|||||||||:||||||||:|||||||||||||||||
 Frog   196 ELNASSVGMAKAALEAIDELDLFGAHGGPKSVIHVLPDDVEHCQSILYSMLPRASTSKEIDAGLL 260

Human   261 SIISFPAFAVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKLFENIE 325
            ||||:|||||||:|||||||||||:|||||||||||||||:|||||||.|||||..|||||||||
 Frog   261 SIISYPAFAVEDINLVNVTKNEIITKLQGRYGCCRFLRDGFKTPREDPTRLHYDSTELKLFENIE 325

Human   326 CEWPVFWTYFIIDGVFSGDAVQVQEYREALEGILIRGKNGIRLVPELYAVPPNKVDEEYKNPHTV 390
            ||||:||||.:|||:|:||.||:||||||||||||||||||||||||||||.:|::|||.|||||
 Frog   326 CEWPLFWTYLLIDGIFNGDQVQMQEYREALEGILIRGKNGIRLVPELYAVPTDKIEEEYHNPHTV 390

Human   391 DRVPMGKVPHLWGQSLYILSSLLAEGFLAAGEIDPLNRRFSTSVKPDVVVQVTVLAENNHIKDLL 455
            ||.|:||:|||||||||||.|||||||||.||:|||||||||..||||||||:||||:..||.:|
 Frog   391 DRRPLGKIPHLWGQSLYILGSLLAEGFLAPGEVDPLNRRFSTVFKPDVVVQVSVLAESKEIKKML 455

Human   456 RKHGVNVQSIADIHPIQVQPGRILSHIYAKLGRNKNMNLSGRPYRHIGVLGTSKLYVIRNQIFTF 520
            :.||:.|||.:|:.||:|||.|||||:|||||.||.|.||||||||||||||||||:||||||||
 Frog   456 KNHGLEVQSFSDVRPIRVQPARILSHLYAKLGHNKAMKLSGRPYRHIGVLGTSKLYMIRNQIFTF 520

Human   521 TPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWRMTGRPTLTFPISRTMLTNDGSDIHSAVLST 585
            |||||||||||||||:.|||||||.|||||.:||||||||||||||:.:||..|||||..|:|||
 Frog   521 TPQFTDQHHFYLALDSRMIVEMLRTELAYLTSCWRMTGRPTLTFPITHSMLNEDGSDIDPAILST 585

Human   586 IRKLEDGYFGGARVKLGNLSEFLTTSFYTYLTFLDPDCDEKLFDNASEGTFSPDSDSDLVGYLED 650
            |||:|||||||||||||.||:||||||||:|:|||.|||.||||:..:..:||.:|.::..:...
 Frog   586 IRKMEDGYFGGARVKLGKLSDFLTTSFYTHLSFLDSDCDGKLFDDVDDECYSPVNDYEVELFSNT 650

Human   651 TC------NQESQDELDHYINHLLQSTSLRSYLPPLCKNTEDRHVFSAIHSTRDILSVMAKAKGL 709
            .|      .:|.|||||.|||.|.||.:..|||||:..::...|.||.:||||||||:|||:|||
 Frog   651 ECEKGNITKEEVQDELDQYINQLQQSMASTSYLPPISSHSGTYHAFSTLHSTRDILSIMAKSKGL 715

Human   710 EVPFVPMTLPTKVLSAHRKSLNLVDSPQPLLEKVPESDFQWPRDDHGDVDCEKLVEQLKDCSNLQ 774
            :||...:.||.|.|||||:||||::.||....:..|::...|:|.|||:||.||:::||:|..||
 Frog   716 DVPNSSLFLPAKNLSAHRRSLNLLEVPQLHKHQNHETELNLPKDAHGDIDCHKLLDKLKECPTLQ 780

Human   775 DQADILYILYVIKGPSWDTNLSGQHGVTVQNLLGELYGKAGLNQEWGLIRYISGLLRKKVEVLAE 839
            |||||||||.||||..|||.|:||.||:|..||.|||.|||||:||||||||||||:|:||||||
 Frog   781 DQADILYILCVIKGLDWDTGLNGQCGVSVHLLLNELYSKAGLNREWGLIRYISGLLKKRVEVLAE 845

Human   840 ACTDLLSHQKQLTVGLPPEPREKIISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRA 904
            ||||:|||.||||||||||||||.|:||||||:|..|||||||||||||||||||::|||||||:
 Frog   846 ACTDILSHHKQLTVGLPPEPREKTITAPLPPEQLAALIYEASGQDISIAVLTQEIMLYLAMYVRS 910

Human   905 QPSLFVEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSGKEFGVERS 969
            |||||.||||||||||:|||||||||||||||||||||||:||||||||||||||||||||||||
 Frog   911 QPSLFGEMLRLRIGLIMQVMATELARSLNCSGEEASESLMSLSPFDMKNLLHHILSGKEFGVERS 975

Human   970 VRPIHSSTSSPTISIHEVGHTGVTKTERSGINRLRSEMKQMTRRFSADEQFFSVGQAASSSAHSS 1034
            :|||.||.:||.|||||:||||.|||||||||:||:|||||.||||.|:||   |.:.:||.||:
 Frog   976 MRPIESSATSPAISIHEMGHTGATKTERSGINKLRNEMKQMDRRFSQDDQF---GHSVASSIHSA 1037

Human  1035 KSAVTVPRDYCRSSTPSSPTGT-SSSDSGGHHIGWGERQGQWLRRRRLDGAINRVPVGFYQRVWK 1098
            :|.        |.|:||||||| |.:...|.|:.:.:.||||||||||||||||||||||||||.
 Frog  1038 RST--------RCSSPSSPTGTLSPTGFVGPHLVFDDHQGQWLRRRRLDGAINRVPVGFYQRVWN 1094

Human  1099 ILQKCHGLSIDGYVLPSSTTREMTPHEIKFAVHVESVLNRVPQPEYRQLLVEAIMVLTLLSDTEM 1163
            :|||||||||||||||||:|||||..|||||||||||||.||||||||||||||.||||:||.|:
 Frog  1095 VLQKCHGLSIDGYVLPSSSTREMTACEIKFAVHVESVLNHVPQPEYRQLLVEAINVLTLVSDMEV 1159

Human  1164 TSIGGIIHVDQIVQMASQLFLQDQVSIGAMD-TLEKDQATGICHFFYDSAPSGAYGTMTYLTRAV 1227
            .|.|.|||||:||..|:.||||||.::||.| .|:.|||||||:||||||||||||||||||:||
 Frog  1160 DSFGSIIHVDRIVHSANDLFLQDQKALGAADFYLDLDQATGICNFFYDSAPSGAYGTMTYLTKAV 1224

Human  1228 ASYLQELLPNSGCQMQ 1243
            |..||:.|||:.|.||
 Frog  1225 AISLQDFLPNTSCSMQ 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHKA2	NP_001427734.1	Calmodulin-binding. /evidence=ECO:0000255	807..837		24/29 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..998		19/25 (76%)
		Calmodulin-binding. /evidence=ECO:0000255	1067..1107		32/39 (82%)
phka2	XP_012812949.2	Glyco_hydro_15	8..>439	CDD:395586	383/430 (89%)
		Bac_rhamnosid6H	<808..925	CDD:481215	97/116 (84%)
		KPBB_C	936..>1151	CDD:437124	171/225 (76%)