Protein Alignment PHEX and Nepl11

DIOPT Version :9

• Sequence 1: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 138/709 - (19%)
• Similarity: 248/709 - (34%)
• Gaps: 204/709 - (28%)

Human    70 VNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDL------KLKELL-EKSISRRR 127
            ::.|..||.:|:.:.|.                      |:.:|      :.:.|| |..:::..
  Fly    39 LDTSKQPCQDFYGYVCS----------------------HSANLSETGRQRFQSLLKETDVAQLM 81

Human   128 DTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLA 192
            |.| :|... .:.||.:.:.:|......|   .|.|. .||.||    |..|.:.::.:..|...
  Fly    82 DME-LQLIN-FFKSCESGRGVEALKGSQL---YRQSG-GWPSLE----PNKVNASQRTNQTQRWL 136

Human   193 TFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTA 257
            ...|.:........:.:.....||:.::.|.             .:.|.    |:.|.||.....
  Fly   137 GLLGYFHEVGAPYFFETSVTMQSNKRLVVLQ-------------PDGTR----RNTLRKFEQRVG 184

Human   258 VLL---GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISEL---SAMIPQFDWLG 316
            .:|   |...|||......||.||....:| :..::...:..::..|...:   :|.:.:.||.|
  Fly   185 EVLQSFGIEQSRAHVTALEVLSLERSRRDI-VKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDG 248

Human   317 YIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWR-----MVYSRIP 376
            |.:|::..      |....|:.:||:......:.|.:|.:.....:.|: :|.     :|.:...
  Fly   249 YFRKLLGG------KTPQASDTIVVKQLPRLVEYFALLQNTSMVRLLNW-IWTDYLMDIVDADCH 306

Human   377 NLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPY-VVGKMFVDVYFQEDKKEMMEELVE 440
            .||.  .|....::.|:|..|         .|.:|.|..| .:||.:.|            :|..
  Fly   307 QLSE--TYAGDLYAHVVQRVT---------ANRVELAQMYSELGKAYTD------------QLGG 348

Human   441 GVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGN 505
            .|             |:|    ..:::.:|..|..:.:.. :..|..::....:|.......:.|
  Fly   349 SV-------------WID----EISRQSSRQFLGNIMHTT-LNGDERLDAAYHSILLGRRSLYRN 395

Human   506 VLQTRKY-----LAQSDFFWLRKAVPKTEWFTNPTTVNAF---YSASTNQIRFPAGELQKPFFWG 562
            :.:.||:     ||......:|:   ..:.|   ..||||   ::.||
  Fly   396 LEKLRKFQRTRRLASHSAQQVRR---YAQMF---APVNAFLGQHNLST----------------- 437

Human   563 TEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
                 .|:|    :::|..|:......|......|   .|.|::||.:|....:|:
  Fly   438 -----PLNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV--------- 481

Human   628 KKAGLNVKGKRT-----LGENIADNGGLREAFRAYRKWINDRRQGLEE----PLLPGIT-FTNNQ 682
                    ||:|     |...:|.    |:|..||.:|: ..:.||.|    .|..|.: .:..:
  Fly   482 --------GKQTNAIDLLLSLLAQ----RQALSAYGQWL-ATQAGLVERVDAVLAAGSSKMSLQR 533

Human   683 LFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFR--VNGAISNFEEFQKAFNCPPNSTM 739
            |||::...|.|.|          ::||....:.|  .:..:.|..||.:||.|.|...:
  Fly   534 LFFVTSLLVDCRS----------ELGALQQDRKRQVTHATLRNSPEFLEAFRCRPGDVL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHEX	NP_000435.3	M13	74..747	CDD:189000	137/705 (19%)
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	137/703 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810