Protein Alignment ABCB1 and Mdr65

DIOPT Version :10

• Sequence 1: NP_001335874.1
• Gene: ABCB1 / 5243
• HGNCID: 40
• Length: 1350
• Species: Homo sapiens
• Sequence 2: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Alignment Length: 1312
• Identity: 550/1312 - (41%)
• Similarity: 794/1312 - (60%)
• Gaps: 79/1312 - (6%)

Human    91 NKSEKDKKEKKP---------TVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMT 146
            :.||...:|:.|         .::...:||:|.:.:..::..|.:...|....||.:::::.|.|
  Fly     9 SSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFT 73

Human   147 DI-------FANAGNLEDLM-----SNITN--RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLV 197
            .:       |..:.|:..|.     ..:||  |.:.|:.     |.:|...|....:.....:.:
  Fly    74 SMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEA-----LYDDSISYGILLTIASVVMFI 133

Human   198 AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGM 262
            :....|..:.:.|.||:.::|.:.|.:::||:|||.|:.........:.|||.||.:||.:|:|.
  Fly   134 SGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGH 198

Human   263 FFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEV 327
            |...:..|.....:.|:.||||||.:.:..|::.|.....||.....|.:|..:||.||.:|||:
  Fly   199 FVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEI 263

Human   328 LAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVL 392
            |::||||::|||:|.|::||...|..|::....|...:.:|......::|.|.|.|||||..|::
  Fly   264 LSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLII 328

Human   393 ------SGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKS 451
                  :.||:...::..||.:::||.::.:.:|.:|:||.|||.|..:||:||....||..|..
  Fly   329 DDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTD 393

Human   452 GHKPD-NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 515
            |...: .::|::||::|.|.||||.||.:.:|||:::::||||||||:|||||||.|||:||.||
  Fly   394 GKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYD 458

Human   516 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY 580
            |..|.|.:|..|||..|:::||..|.||.||||||..|||:||.||:...|..|||.|..:|.|:
  Fly   459 PVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAH 523

Human   581 DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDK 645
            :||..||..:.:::||||:||||||||||||||||::|||||||||||||||.:||..||.|||.
  Fly   524 EFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDL 588

Human   646 ARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG-----NEV 705
            |.|||||||::||||.:|.||.|....||.::|:|:||:||..:|.|:.:|   .||     :||
  Fly   589 ASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAGDINMPDEV 650

Human   706 ELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQ------AQDRKLSTKEALDESIPP 764
            |.|::.:::|.:..||...|.:: |.|..::..:.||:..:      .:|....:.||     ||
  Fly   651 EKEDSIEDTKQKSLALFEKSFET-SPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEA-----PP 709

Human   765 V------SFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSN 823
            .      :|.||::|...||.|.::|...|:..|.|.||||:||.:....... .|||...:.:.
  Fly   710 EKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAE-KDPEDALRRTA 773

Human   824 LFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRL 888
            :.|...|.|..::.:..|||.:.|..||..||.|:|.|.|.:|:.|:|.||||..|:.|||:.||
  Fly   774 VLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARL 838

Human   889 ANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA 953
            :.:|..::||||..|:.:.|.::|..:.:.::..|.|:|.||.||..|||..:.::|.||:|...
  Fly   839 SGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAV 903

Human   954 LKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQ---VPYRNSLRKAHIFGITFSFT 1015
            :::|:.:|.:.:||||:|.|.|||..|.:|......|.:.:|   |..|..||..   |:..|..
  Fly   904 VREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWR---GVLNSTM 965

Human  1016 QAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIM 1080
            ||..:|:||....:|..||:...:.|:|::.|...:::|:|.:.|..:|.|.::.|.|:...:..
  Fly   966 QASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQ 1030

Human  1081 IIEKTPLIDSYSTEGLMPNTL-------EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLAL 1138
            |:::.|.|.  |..|.:.|||       || |.:..:.|.||||||..:|.||.|||.||||:||
  Fly  1031 ILDRKPKIQ--SPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVAL 1092

Human  1139 VGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKR-LNVQWLRAHLGIVSQEPILFDCSIAENIA 1202
            ||.|||||||.||||:|:|||..|.:.:|..:|:. |.:..:|..||||||||.||:.|||||||
  Fly  1093 VGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIA 1157

Human  1203 YGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1267
            ||||.|.||..||:.|||.||.|:||.||||.|.|::|.:||||||||||||||||||||.|.||
  Fly  1158 YGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKIL 1222

Human  1268 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1332
            ||||||||||.:||::||:|||.|..|||||||||||||:||||:|.|.|||:|.|.|.|.||::
  Fly  1223 LLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS 1287

Human  1333 QKGIYFSMVSVQ 1344
            |.|||..:...|
  Fly  1288 QGGIYAKLHKTQ 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	540/1262 (43%)
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	233/525 (44%)
		MdlB	711..1299	CDD:440747	275/594 (46%)