Protein Alignment ABCB1 and Mdr49

DIOPT Version :10

• Sequence 1: NP_001335874.1
• Gene: ABCB1 / 5243
• HGNCID: 40
• Length: 1350
• Species: Homo sapiens
• Sequence 2: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Alignment Length: 1344
• Identity: 566/1344 - (42%)
• Similarity: 807/1344 - (60%)
• Gaps: 112/1344 - (8%)

Human    65 KEREVGMDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAI 129
            |:.|..:...||          |:|...|..|...|   .|.|.:||||...::..:||..|.|.
  Fly     3 KKEESRLPQAGD----------FQLKEGSVVDATRK---YSYFDLFRYSTRCERFLLVVSLLVAT 54

Human   130 IHGAGLPLMMLVFGEMTDI-------------------FANAGNLEDLMSNITNRSDINDTGFFM 175
            ...|.:|..|:::||.|.:                   |.....|.:......|::.|:|...|
  Fly    55 AASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAF- 118

Human   176 NLEEDMTRYAYYYSGIGAGV-LVAAYIQVSFWCLAAGR----QIHKIRKQFFHAIMRQEIGWFDV 235
                          |||:.| .||.::.::.....|.|    ||.:|||.|..|::||:|.|:|.
  Fly   119 --------------GIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDT 169

Human   236 HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 300
            .......:::|:|:.|:.||||:||.:....:.||..|.:..|..|||||||:|:..|.:..:.:
  Fly   170 SSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATS 234

Human   301 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITA 365
            |.|::..|..:|||.:|:.|..|.|||.:.||||.||.||:||.||:.|.|..|:..|.||.:.:
  Fly   235 VVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYS 299

Human   366 NISIGAAFLLIYASYALAFWYGTTLVLSGE------YSIGQVLTVFFSVLIGAFSVGQASPSIEA 424
            .:....::|:||...|||.|||.||:|...      |:...::.|.|:|::||.::|.|||.:||
  Fly   300 GMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEA 364

Human   425 FANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQS 489
            .|.|..|...:|.|||....:|...:.|::|:|..|::.|..:.|.||:|.:|:|||||.:.|..
  Fly   365 IAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLP 429

Human   490 GQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 554
            |||||.||.|||||||.:|||||.|||..|.|.:||:|:||:||.:||..||||.||||||||||
  Fly   430 GQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTI 494

Human   555 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNP 619
            .|||||||.:.|..:||||.:.||.:|||.:||..:||.|||:|||:||||||||||||||||.|
  Fly   495 GENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQP 559

Human   620 KILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 684
            ::|||||||||||..||..||.||:.|.:|.||:|:||||||:.|||.|....|||:.|:|.|:|
  Fly   560 QVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEE 624

Human   685 LMKEKGIYFKLVTM----------------------QTAGNEVELENAADESKSEIDALEM--SS 725
            ||:.:|:|.:||::                      |...:|...::..||.:.|...|:.  ||
  Fly   625 LMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSS 689

Human   726 NDS--RSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCA 788
            .||  |:|..||   |||.|..:.:|:::.:|         |||.::||||..||.:.|||...:
  Fly   690 RDSGFRASTRRK---RRSQRRKKKKDKEVVSK---------VSFTQLMKLNSPEWRFIVVGGIAS 742

Human   789 IINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEI 853
            :::|...|.:.:.|....|:.:..|| :..|......|::|:.:|:::.:...||.:.|..||..
  Fly   743 VMHGATFPLWGLFFGDFFGILSDGDD-DVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVK 806

Human   854 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGII 918
            :|.|||...|.:::.||:::|||.:|:.|||.:|||:|.:.|:||.|:|:..:.|.:|.|..|::
  Fly   807 MTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMV 871

Human   919 ISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQE 983
            :.|::.||.|||.|..:|::.::..:|.:.:...|.|.|..:|.:.::|.|||.|.|||..|..|
  Fly   872 VGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLE 936

Human   984 QKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVF 1048
            ::....|.|.:........||....|:.|:..||..:.:|.....:|..|||.:.|::||::.|.
  Fly   937 RQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVA 1001

Human  1049 SAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMP----NTL---EGNVT 1106
            .|::||:..:||..::||:...|.:||..::.:.::|      ||:...|    ||:   ||::.
  Fly  1002 EALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRT------STQPNPPQSPYNTVEKSEGDIV 1060

Human  1107 FGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1171
            :..|.|.||||...|:||||:|.:||..|:||||.||.||||.||||.|:|||::|.|.|.|...
  Fly  1061 YENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPS 1125

Human  1172 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR-VVSQEEIVRAAKEANIHAFIESLPNKY 1235
            ....:..||:.||:|||||:|||.:||||||||:|.| .||.:||:.|||::|||.||.:||..|
  Fly  1126 TEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGY 1190

Human  1236 STKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVI 1300
            .|::| |.:||||||||||||||||||.|.||:|||||||||.|||||||:|||:||.||||:.|
  Fly  1191 DTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTI 1254

Human  1301 AHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1344
            ||||:|::|||||.|.:.|.|.|||||.:|:|...||.::..:|
  Fly  1255 AHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQ 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	547/1277 (43%)
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	272/613 (44%)
		MdlB	720..1299	CDD:440747	258/587 (44%)