Protein Alignment ABCB1 and CG11147

DIOPT Version :10

• Sequence 1: NP_001335874.1
• Gene: ABCB1 / 5243
• HGNCID: 40
• Length: 1350
• Species: Homo sapiens
• Sequence 2: NP_608954.1
• Gene: CG11147 / 33803
• FlyBaseID: FBgn0031734
• Length: 711
• Species: Drosophila melanogaster
• Alignment Length: 804
• Identity: 161/804 - (20%)
• Similarity: 274/804 - (34%)
• Gaps: 263/804 - (32%)

Human   462 LEFRNVHFSYPSRKEVKI-LKGLNLKVQSGQTVALVGNSGCGKSTTVQLM--QRLYDPTEGMV-- 521
            :|.||.:..|.|:...|| |..||:.|..|....|:|.|||||:|.:..:  ||..:..|.:|
  Fly     4 VEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLG 68

Human   522 ---SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENI-----RYGRENVTMDEIEKAVKEAN 578
               ...|..:....|.|:.:.|.:|.:      .|:.|.|     .||..:..:.|..|.:||
  Fly    69 AKPGEPGSGVPGSRVGFMPQEIALVEE------MTVKETIFYFGRIYGLTDERIREKFKLLKE-- 125

Human   579 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAVVQVA 642
                :::||.....:     .|.||||::|::.|.|::.:|::|:|||.|..||.. .|.:....
  Fly   126 ----LLQLPPARQMI-----KQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFL 181

Human   643 LDKARKGRTTIVI-AHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIY-----FKLVTMQTA 701
            ::..|..:..::| .|.:...:.|:.|....:||::.:.....:|.:.|..     | |:..|..
  Fly   182 VETTRNSKLAVIITTHYIEEAKQANCIGLMRNGVLLAEDTPTNIMIKFGTQSIEDAF-LILSQRQ 245

Human   702 GNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVS 766
            |||.||....|.:|                             :||....:...|.:|...|
  Fly   246 GNEDELAQIMDHNK-----------------------------NQALPAAVLPPEVIDTHEP--- 278

Human   767 FWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLA 831
                   |:.|                .||.                 |..:..|.|...:.|.
  Fly   279 -------NMPE----------------KQPI-----------------PFEEPLNENRKKIFFT- 302

Human   832 LGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVK 896
                          |.|:...::||.     |..:.||.
  Fly   303 --------------TKGRVKALMTKN-----FVQLFRQP-------------------------- 322

Human   897 GAIGSRLAVITQNIANLGTGIIISFIYG-WQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKEL 960
                              :|||...::. .|||...|||
  Fly   323 ------------------SGIIFMLLFPIIQLTCFYLAI-------------------------- 343

Human   961 EGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFG-ITFSFTQAM------ 1018
               ||..|    |....|...:.:.:...:.::|...|::|..::.:|. ::..:.:.:
  Fly   344 ---GKTPT----NLEIGVYSGEVENYGECFDENLVTVYKDSDNESCLFNKLSCRYIRVLGDDVAT 401

Human  1019 --MYFSYAGCFRFG------AYLVAHKLMSFEDVLLVFSAVVFGAMAVG-QVSSFAPDYAKAKIS 1074
              .|.|.|......      .||  |...:|.|.:|       ..|..| ..|..|.|:|:..|
  Fly   402 RKYYASEADALNDAKRATTVGYL--HFAQNFSDSIL-------SVMEDGIHSSDGAVDHAELSI- 456

Human  1075 AAHIIMIIEKT------PLIDSYSTEGLMPNTLEG-NVTFGEVVFNYPTRPDIPVLQGLSLEVKK 1132
              ||.|..::.      .|.|.:||  .|.:.::. ||:  ..:.:.|.:...|:.....:|.::
  Fly   457 --HIDMTDQQVAYFMQRKLRDKFST--FMRSVVKDCNVS--TAIVDLPVQFQEPIFGSTDIEFQQ 515

Human  1133 ----GQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHL-------GIV 1186
                |..:.:|.......:..|.:.||. |.:..:.||.|  :....:.|  |||       .:.
  Fly   516 YCAPGVVMTMVFFLATLMTAAVFISERM-DGIWDRTLLAG--VSATEMLW--AHLLTQLIIMALQ 575

Human  1187 SQEPILFDCSIAENIAYGDNSRVV 1210
            |.|.|::...:.:....||.:.::
  Fly   576 SFEVIMYIGLVFDTYNNGDTTTLI 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	161/804 (20%)
CG11147	NP_608954.1	CcmA	4..245	CDD:440746	69/258 (27%)
		ABC2_membrane_3	322..702	CDD:463674	65/376 (17%)
		YadH	513..710	CDD:440604	18/92 (20%)