DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcn3 and CG31650

DIOPT Version :9

Sequence 1:	NP_001341974.1	Gene:	Rcn3 / 52377	MGIID:	1277122	Length:	328	Species:	Mus musculus
Sequence 2:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	109/306 - (35%)
Similarity:	167/306 - (54%)	Gaps:	24/306 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    31 QDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGR-DVAKEFDKLSPEESQARLGRIVDRMDLAGDSD 94
            :|..|||        :|...|.::||||.:|. ..|:|||.|||:||:.||..::..|||  :.|
  Fly    53 RDAHHHG--------EDGEHNVEFDHEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDL--NKD 107

Mouse    95 GWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFH----DV 155
            .::...||:|||..:.::...:..:..:...|.|.|.|:.|:|....||...:  |:|.    |.
  Fly   108 EFIDRHELKAWILRSFKKLSEEEAADRFEEIDQDADERITWKEYLQDTYAMED--EDFKKETIDY 170

Mouse   156 EDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYV 220
            :..|..:||:.:|:..|..||.:.|.:.|.||...|.:|||.|.|..|::..|::|.|.:.||.:
  Fly   171 DSYEDEQKMIKQDKEMFNAADTNKDGVLTLEEFVLFQNPEEHPQMLPILLEHTMQDKDADHDGKI 235

Mouse   221 QVEEYIADLYSEEPGEEEPAWVQTERQQFREFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHL 285
            ..:|::.|..|....|    |:.||:::|.:..|.|.||.|.|.||..|::|.:......|.:||
  Fly   236 NFQEFVGDAASHHDKE----WLITEKERFDKDHDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHL 296

Mouse   286 LHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTR-HH--DEL 328
            ...:|.|.|.|||..|||:|::.||||:||:||:.|.. :|  |||
  Fly   297 FVSTDEDHDDRLSYLEILNNYDTFVGSEATDYGDHLQNINHLSDEL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcn3	NP_001341974.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..48		4/16 (25%)
		EFh_CREC_RCN3	44..311	CDD:320028	93/271 (34%)
		EF-hand motif	44..73	CDD:320028	12/29 (41%)
		EF-hand motif	79..110	CDD:320028	11/30 (37%)
		EF-hand motif	117..146	CDD:320028	8/28 (29%)
		EF-hand motif	167..196	CDD:320028	10/28 (36%)
		EF-hand motif	204..233	CDD:320028	8/28 (29%)
		EF-hand motif	245..274	CDD:320028	12/28 (43%)
		EF-hand motif	281..311	CDD:320028	14/29 (48%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	325..328		2/4 (50%)
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	15/54 (28%)
		EFh	100..153	CDD:298682	15/54 (28%)
		EF-hand_7	184..241	CDD:290234	20/56 (36%)
		EFh	184..241	CDD:298682	20/56 (36%)
		EFh	228..281	CDD:298682	19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820