Protein Alignment PGK1 and pgk1

DIOPT Version :10

• Sequence 1: NP_000282.1
• Gene: PGK1 / 5230
• HGNCID: 8896
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001016545.1
• Gene: pgk1 / 549299
• XenbaseID: XB-GENE-947126
• Length: 417
• Species: Xenopus tropicalis
• Alignment Length: 417
• Identity: 359/417 - (86%)
• Similarity: 394/417 - (94%)
• Gaps: 0/417 - (0%)

Human     1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLG 65
            |||||||||||:|||||||||||||||||||||||||||||||||||:.|||:||||||||||||
 Frog     1 MSLSNKLTLDKVDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIQHCLDHGAKSVVLMSHLG 65

Human    66 RPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEG 130
            |||||||||||||.|||.|||:|:.::::|||||||||||.|||:||.|:|:|||||||||||||
 Frog    66 RPDGVPMPDKYSLAPVAEELKALMKREIVFLKDCVGPEVEAACADPAPGTVLLLENLRFHVEEEG 130

Human   131 KGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELN 195
            |||||:||||||:.||::|||||||||||||:|||||||||||||||||.|||:|.||||||||:
 Frog   131 KGKDAAGNKVKADAAKVDAFRASLSKLGDVYINDAFGTAHRAHSSMVGVKLPQRAAGFLMKKELD 195

Human   196 YFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDE 260
            |||||||:||||||||||||||.|||||||||||||||||||||||||||||||||.||.||:||
 Frog   196 YFAKALENPERPFLAILGGAKVKDKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMSIGNSLYDE 260

Human   261 EGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325
            ||||||||||:|||||||||||||||.||:||||||.||.|:|::|||.|||||||||||.|.:.
 Frog   261 EGAKIVKDLMAKAEKNGVKITLPVDFTTAEKFDENAGTGHASVSTGIPDGWMGLDCGPESMKLFV 325

Human   326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVS 390
            |||.||||||||||||||||:.||:||||:||:||:.|.:||||||||||||||||||:||||||
 Frog   326 EAVGRAKQIVWNGPVGVFEWDNFAKGTKAVMDKVVEVTGKGCITIIGGGDTATCCAKWDTEDKVS 390

Human   391 HVSTGGGASLELLEGKVLPGVDALSNI 417
            ||||||||||||||||||||||||||:
 Frog   391 HVSTGGGASLELLEGKVLPGVDALSNV 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGK1	NP_000282.1	PTZ00005	3..417	CDD:173310	356/413 (86%)
		Mitochondrial targeting region exposed following cis-trans isomerization by PIN1 and recognized by the TOM complex for mitochondrial translocation of the protein. /evidence=ECO:0000269|PubMed:26942675	38..43		4/4 (100%)
pgk1	NP_001016545.1	PTZ00005	3..416	CDD:173310	355/412 (86%)