Protein Alignment PGK1 and pgk1

DIOPT Version :10

• Sequence 1: NP_000282.1
• Gene: PGK1 / 5230
• HGNCID: 8896
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_998552.1
• Gene: pgk1 / 406696
• ZFINID: ZDB-GENE-040426-2711
• Length: 417
• Species: Danio rerio
• Alignment Length: 417
• Identity: 368/417 - (88%)
• Similarity: 388/417 - (93%)
• Gaps: 0/417 - (0%)

Human     1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLG 65
            |||||||.|||:|||||||:||||||||||||.||||||||||||||:.||||.||:|.||||||
Zfish     1 MSLSNKLHLDKVDVKGKRVIMRVDFNVPMKNNVITNNQRIKAAVPSIQHCLDNCAKAVALMSHLG 65

Human    66 RPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEG 130
            |||||||||||||||||.|||:||||||.||||||||:||||||:|.||||||||||||||.|||
Zfish    66 RPDGVPMPDKYSLEPVAAELKNLLGKDVQFLKDCVGPDVEKACADPPAGSVILLENLRFHVAEEG 130

Human   131 KGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELN 195
            |||||||||.||..|:|:|||||||||||||||||||||||||||||||||||||.||||||||:
Zfish   131 KGKDASGNKTKASQAEIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAAGFLMKKELD 195

Human   196 YFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDE 260
            |||.|||.|:||||||||||||.||||||||||||||||||||||||||||||.|||||||||||
Zfish   196 YFAMALEKPQRPFLAILGGAKVKDKIQLINNMLDKVNEMIIGGGMAFTFLKVLKNMEIGTSLFDE 260

Human   261 EGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325
            ||:.||||||:|||||||||||||||:|||||||.|.||.||||.|||||||||||||||||.||
Zfish   261 EGSTIVKDLMAKAEKNGVKITLPVDFITADKFDEKATTGTATVAEGIPAGWMGLDCGPESSKLYA 325

Human   326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVS 390
            |||.||||||||||||||||:.||.|||.:||:||:||..||||||||||||||||||:||||||
Zfish   326 EAVARAKQIVWNGPVGVFEWDNFAHGTKNMMDKVVEATKNGCITIIGGGDTATCCAKWDTEDKVS 390

Human   391 HVSTGGGASLELLEGKVLPGVDALSNI 417
            ||||||||||||||||||||||||||:
Zfish   391 HVSTGGGASLELLEGKVLPGVDALSNV 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGK1	NP_000282.1	PTZ00005	3..417	CDD:173310	365/413 (88%)
		Mitochondrial targeting region exposed following cis-trans isomerization by PIN1 and recognized by the TOM complex for mitochondrial translocation of the protein. /evidence=ECO:0000269|PubMed:26942675	38..43		4/4 (100%)
pgk1	NP_998552.1	PTZ00005	3..416	CDD:173310	364/412 (88%)