Protein Alignment PGK1 and pgk1

DIOPT Version :10

• Sequence 1: NP_000282.1
• Gene: PGK1 / 5230
• HGNCID: 8896
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_596730.1
• Gene: pgk1 / 2539764
• PomBaseID: SPBC14F5.04C
• Length: 414
• Species: Schizosaccharomyces pombe
• Alignment Length: 416
• Identity: 278/416 - (66%)
• Similarity: 335/416 - (80%)
• Gaps: 3/416 - (0%)

Human     1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLG 65
            ||||.||.:..:|:|||.|::|||||||:..::||||.||..|:|:||:.|:...|:|:||||||
pombe     1 MSLSTKLAITDVDLKGKNVLIRVDFNVPLDGDRITNNARIVGALPTIKYALEQQPKAVILMSHLG 65

Human    66 RPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEG 130
            ||:|..:. ||||:|||.||..||||.|.||.|||||||||||.....|.||||||||||:||||
pombe    66 RPNGARVA-KYSLKPVAAELSKLLGKPVKFLDDCVGPEVEKACKEAKGGEVILLENLRFHIEEEG 129

Human   131 KGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELN 195
            ..| ..|.||||:.:.:||||.||:.|||::||||||||||||||||||:|| :..||||||||:
pombe   130 SAK-VDGKKVKADASAVEAFRKSLTSLGDIFVNDAFGTAHRAHSSMVGVDLP-RVSGFLMKKELD 192

Human   196 YFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDE 260
            ||:||||:|.|||||||||||||||||||:|:|||||.:||.||||||||||||.|:||.|||||
pombe   193 YFSKALENPARPFLAILGGAKVADKIQLIDNLLDKVNRLIICGGMAFTFLKVLNGMKIGDSLFDE 257

Human   261 EGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325
            .|:|.|:.:|:||:||.|::.||||||||||||::||.|.||...|||.|||||||||:||.|:|
pombe   258 AGSKNVESMMAKAKKNNVEVFLPVDFVTADKFDKDAKVGSATAEEGIPDGWMGLDCGPKSSAKFA 322

Human   326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVS 390
            |.:|.:|.||||||.||||::.||:|||:::|..||....|.:.|:|||||||...|:..||.:|
pombe   323 EVITTSKTIVWNGPAGVFEFDNFAKGTKSMLDACVKTCEAGNVVIVGGGDTATVAKKYGKEDALS 387

Human   391 HVSTGGGASLELLEGKVLPGVDALSN 416
            ||||||||||||||||.||||.|||:
pombe   388 HVSTGGGASLELLEGKALPGVVALSS 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGK1	NP_000282.1	PTZ00005	3..417	CDD:173310	276/414 (67%)
		Mitochondrial targeting region exposed following cis-trans isomerization by PIN1 and recognized by the TOM complex for mitochondrial translocation of the protein. /evidence=ECO:0000269|PubMed:26942675	38..43		2/4 (50%)
pgk1	NP_596730.1	PTZ00005	3..414	CDD:173310	276/414 (67%)