Protein Alignment PGK1 and pgk-1

DIOPT Version :10

• Sequence 1: NP_000282.1
• Gene: PGK1 / 5230
• HGNCID: 8896
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_491245.1
• Gene: pgk-1 / 171965
• WormBaseID: WBGene00020185
• Length: 417
• Species: Caenorhabditis elegans
• Alignment Length: 415
• Identity: 302/415 - (72%)
• Similarity: 349/415 - (84%)
• Gaps: 1/415 - (0%)

Human     1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLG 65
            ||..|||.:|:|::.||||::|||||||:|:.:|||||||.||||:|:..|.|||||||||||||
 Worm     1 MSSLNKLAIDQLNLAGKRVLIRVDFNVPLKDGKITNNQRIAAAVPTIQHALSNGAKSVVLMSHLG 65

Human    66 RPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEG 130
            |||| ...|||:|:|||.|||:||.||||||.||||.|||.|||:||.||||||||||:|:||||
 Worm    66 RPDG-RRQDKYTLKPVAEELKALLKKDVLFLDDCVGSEVEAACADPAPGSVILLENLRYHLEEEG 129

Human   131 KGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELN 195
            ||.||||.||||:.|.::.||.||:||||:|||||||||||||||||||...|:|.|||:|.||:
 Worm   130 KGVDASGAKVKADSAAVKKFRESLTKLGDIYVNDAFGTAHRAHSSMVGVEHSQRASGFLLKNELS 194

Human   196 YFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDE 260
            ||:|||::|.|||||||||||||||||||.|:||||||||||||||:|||||...::||.||:||
 Worm   195 YFSKALDNPARPFLAILGGAKVADKIQLIKNLLDKVNEMIIGGGMAYTFLKVAQGVKIGNSLYDE 259

Human   261 EGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325
            ||||||.:|:..|:..||:|.||||||.||||.|:|.:...|...|:|.|.||||.||||||.:|
 Worm   260 EGAKIVNELLEAAKAKGVQIHLPVDFVIADKFAEDATSKTVTAEEGVPDGHMGLDVGPESSKIFA 324

Human   326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVS 390
            .|:.|||.||||||.||||::.||.|||:|||||||||:.|.|||||||||||...|:|||||||
 Worm   325 AAIQRAKTIVWNGPAGVFEFDKFATGTKSLMDEVVKATAAGAITIIGGGDTATAAKKYNTEDKVS 389

Human   391 HVSTGGGASLELLEGKVLPGVDALS 415
            |||||||||||||||||||||||||
 Worm   390 HVSTGGGASLELLEGKVLPGVDALS 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGK1	NP_000282.1	PTZ00005	3..417	CDD:173310	300/413 (73%)
		Mitochondrial targeting region exposed following cis-trans isomerization by PIN1 and recognized by the TOM complex for mitochondrial translocation of the protein. /evidence=ECO:0000269|PubMed:26942675	38..43		3/4 (75%)
pgk-1	NP_491245.1	PTZ00005	5..414	CDD:173310	298/409 (73%)