Protein Alignment ATP6V1A and Vha68-1

DIOPT Version :10

• Sequence 1: NP_001681.2
• Gene: ATP6V1A / 523
• HGNCID: 851
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_523560.2
• Gene: Vha68-1 / 45668
• FlyBaseID: FBgn0265262
• Length: 614
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 510/614 - (83%)
• Similarity: 560/614 - (91%)
• Gaps: 1/614 - (0%)

Human     4 SKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYE 68
            |.|.|..||::||.:|.|:.||||||||..|:|:|||||||||:.||||||||||||||||||||
  Fly     2 SNLRKFKDEERESEYGRVYAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYE 66

Human    69 ETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKW 133
            |||||:||||||||||||||||||||||:|||||||||.||...|.|||||:|||.:||||...|
  Fly    67 ETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLRDIGVMTNSIYIPKGVNTTALSRSEMW 131

Human   134 DFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEG 198
            :|.|. |:||||||||||:||:|.||:|:|.::::.||.:|||.||||.|||:..|:|||.||:|
  Fly   132 EFNPL-NVRVGSHITGGDLYGVVHENTLVKQRMIVAPRAKGTVRYIAPAGNYNLEDIVLETEFDG 195

Human   199 VKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSL 263
            ...|.||:|||||||.|||||||||||||.|||||||:|||||||||||||||||||||||||:|
  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLFTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260

Human   264 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIY 328
            ||||||||||||||||||||||||||||||||.|:||..||||||||||||||||||||||||||
  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTCEIDGVTESIMKRTALVANTSNMPVAAREASIY 325

Human   329 TGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 393
            ||||||||||||||:|:||||||||||||||||||||||||||||||||||||||:|||||||||
  Fly   326 TGITLSEYFRDMGYNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLATFYERAGRVK 390

Human   394 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYM 458
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455

Human   459 RALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQN 523
            |||||||||::.||||||||.||||||||||:||||||||||||||||:|||||||:||||||||
  Fly   456 RALDEYYDKNYPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKVTLEVAKLLKDDFLQQN 520

Human   524 GYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKD 588
            .|:||||.||||||||||.|::|||:.||.|||:||||||||||:.|||.||.|:|:||||||||
  Fly   521 SYSPYDRVCPFYKTVGMLRNIMAFYETARHAVESTAQSDNKITWNTIRESMGGIMYQLSSMKFKD 585

Human   589 PLKDGEAKIKSDYAQLLEDMQNAFRSLED 617
            |:||||.|||:||.||.||:|.|||:|||
  Fly   586 PVKDGEQKIKADYDQLYEDLQQAFRNLED 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1A	NP_001681.2	V-ATPase_V1_A	17..609	CDD:273411	496/591 (84%)
Vha68-1	NP_523560.2	V-ATPase_V1_A	15..606	CDD:273411	496/591 (84%)