Protein Alignment ATP6V1A and Vha68-2

DIOPT Version :10

• Sequence 1: NP_001681.2
• Gene: ATP6V1A / 523
• HGNCID: 851
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_652004.2
• Gene: Vha68-2 / 45012
• FlyBaseID: FBgn0263598
• Length: 614
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 513/614 - (83%)
• Similarity: 566/614 - (92%)
• Gaps: 1/614 - (0%)

Human     4 SKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYE 68
            |.|.:..||::||.:|.|..||||||||..|:|:|||||||||:.||||||||||||||||||||
  Fly     2 SNLKRFDDEERESKYGRVFAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYE 66

Human    69 ETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKW 133
            |||||:||||||||||||||||||||||:|||||||||.||:..|:|||||:||||.:|||...|
  Fly    67 ETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINELTESIYIPKGVNVPSLSRVASW 131

Human   134 DFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEG 198
            :|.|. |::|||||||||:||:|.||:|:|||:::.||.:|||.||||.|||...|||||.||:|
  Fly   132 EFNPL-NVKVGSHITGGDLYGLVHENTLVKHKMIVNPRAKGTVRYIAPSGNYKVDDVVLETEFDG 195

Human   199 VKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSL 263
            ...|.||:|||||||.|||||||||||||||||||||:|||||||||||||||||||||||||:|
  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260

Human   264 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIY 328
            |||||||||||||||||||||||||||||||::|:||..||||||||||||||||||||||||||
  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELSVEIDGVTESIMKRTALVANTSNMPVAAREASIY 325

Human   329 TGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 393
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   326 TGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 390

Human   394 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYM 458
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455

Human   459 RALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQN 523
            ||||::|||:|.||||||||.||||||||||:||||||||||||||||||||||||:||||||||
  Fly   456 RALDDFYDKNFPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQN 520

Human   524 GYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKD 588
            .|:.||||||||||||||.|:|.||||||.:||:||||:|||||::|||.||:|:|:||||||||
  Fly   521 SYSSYDRFCPFYKTVGMLRNIIDFYDMARHSVESTAQSENKITWNVIREAMGNIMYQLSSMKFKD 585

Human   589 PLKDGEAKIKSDYAQLLEDMQNAFRSLED 617
            |:||||||||:|:.||.||:|.|||:|||
  Fly   586 PVKDGEAKIKADFEQLHEDLQQAFRNLED 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1A	NP_001681.2	V-ATPase_V1_A	17..609	CDD:273411	500/591 (85%)
Vha68-2	NP_652004.2	V-ATPase_V1_A	16..606	CDD:273411	500/590 (85%)