Protein Alignment PGC and CG6508

DIOPT Version :9

• Sequence 1: NP_002621.1
• Gene: PGC / 5225
• HGNCID: 8890
• Length: 388
• Species: Homo sapiens
• Sequence 2: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 154/405 - (38%)
• Similarity: 226/405 - (55%)
• Gaps: 48/405 - (11%)

Human     4 MVVVLVCLQLLEAAV-------VKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGD--L 59
            ::::.:.|.||:.::       :...:.:.|:......||.||           |.||...|  .
  Fly     6 LIIIPLFLLLLDHSMGQLRRTPITRQINQNKTHANVKAEKILL-----------AAKYFLVDRQS 59

Human    60 SVTYEPMAY-MDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQS--QACTSHSRFNPSESS 121
            |.|.:.:|. .:..|...:.||||||.|.:.||||||:||||||.|.|  :||..|:::|.|.||
  Fly    60 SQTTQVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASS 124

Human   122 TYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPA 186
            ::..:|:.||:|||||||:||...||:.:..:.:.||.|..:.:|||:.||...||||:|:|:.:
  Fly   125 SHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFAS 189

Human   187 LSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGS-SGGAVVFGGVDSSLYTGQIYWAPVTQELYW 250
            :| ...||....::::|.:..|||||||.....| |||.|::||:|.|:|.|.|.:.||:...||
  Fly   190 IS-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYW 253

Human   251 Q-----IGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNC 310
            |     :.||..|:       |: |||||.||||||:.||.:...|:.:...|.:...|:..|:|
  Fly   254 QFTANSVKIEGILL-------CN-GCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDC 310

Human   311 NSIQNLPSLTFIINGVEFPLPPSSYIL-----SNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRS 370
            :|:..||::...|.|..:.|.|..||.     :|...|..|.  |||   .|..||||||:||..
  Fly   311 SSLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGF--TYL---QGNLLWILGDIFLGK 370

Human   371 YYSVYDLGNNRVGFA 385
            .|:|:|:|..|:|||
  Fly   371 VYTVFDVGKERIGFA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGC	NP_002621.1	A1_Propeptide	18..46	CDD:285240	5/34 (15%)
		gastricsin	70..387	CDD:133144	139/329 (42%)
		Asp	72..387	CDD:278455	139/327 (43%)
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	139/332 (42%)
		Asp	73..387	CDD:278455	139/327 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151474
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.810