DRSC/TRiP Functional Genomics Resources

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Protein Alignment PGC and Bace

DIOPT Version :9

Sequence 1:NP_002621.1 Gene:PGC / 5225 HGNCID:8890 Length:388 Species:Homo sapiens
Sequence 2:NP_001285756.1 Gene:Bace / 34182 FlyBaseID:FBgn0032049 Length:372 Species:Drosophila melanogaster


Alignment Length:395 Identity:171/395 - (43%)
Similarity:245/395 - (62%) Gaps:33/395 - (8%)


- Green bases have known domain annotations that are detailed below.


Human     2 KWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGE--FLRTHKYDPAWKYRFGDL-SVTY 63
            |.:.||::...|..|.:.:||:.|.::..:|  .:.:|.|  :|||       ||:...| ||..
  Fly     3 KTIAVVVLLAALASAELHRVPILKEQNFVKT--RQNVLAEKSYLRT-------KYQLPSLRSVDE 58

Human    64 EPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNG 127
            |.:: .|:.||:|.||||||.|:|.||||:|||||||||..|:|.||.:|::::.|.||||..||
  Fly    59 EQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANG 123

Human   128 QTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEA 192
            ::||:|||:|||||:...||:.|..:.:.:|.|..|.|||||||..|.||||:|:||.:|:||..
  Fly   124 ESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGV 188

Human   193 TTAMQGMVQEGALTSPVFSVYLSNQQGSS--GGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIE 255
            ......||.:|.:.:.|||.||: :.|:|  ||.::|||.|:|||:|.:.:.|::::.|||.   
  Fly   189 APPFYNMVSQGLVDNSVFSFYLA-RDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQF--- 249

Human   256 EFLIGGQASGW--CSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPS 318
             .:.|....|:  |.: ||||.||||||:..|......|.:.....||.|    ::|:|:.:||.
  Fly   250 -TMAGSSIDGYSLCDD-CQAIADTGTSLIVAPYNAYITLSEILNVGEDGY----LDCSSVSSLPD 308

Human   319 LTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVG 383
            :||.|.|..|.|.||:||:.::|.|....|  |:    |...|||||||:..||:.:||||||:|
  Fly   309 VTFNIGGTNFVLKPSAYIIQSDGNCMSAFE--YM----GTDFWILGDVFIGQYYTEFDLGNNRIG 367

Human   384 FATAA 388
            ||..|
  Fly   368 FAPVA 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PGCNP_002621.1 A1_Propeptide 18..46 CDD:285240 8/29 (28%)
gastricsin 70..387 CDD:133144 149/320 (47%)
Asp 72..387 CDD:278455 149/318 (47%)
BaceNP_001285756.1 pepsin_retropepsin_like 59..369 CDD:299705 149/325 (46%)
Asp 68..371 CDD:278455 149/318 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151471
Domainoid 1 1.000 297 1.000 Domainoid score I1463
eggNOG 1 0.900 - - E1_KOG1339
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 319 1.000 Inparanoid score I2536
Isobase 1 0.950 - 0 Normalized mean entropy S1195
OMA 1 1.010 - - QHG54317
OrthoDB 1 1.010 - - D1619495at2759
OrthoFinder 1 1.000 - - FOG0000066
OrthoInspector 1 1.000 - - mtm8487
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1428
SonicParanoid 1 1.000 - - X1456
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.790

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