DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK14 and Eip63E

DIOPT Version :9

Sequence 1:	NP_001274064.1	Gene:	CDK14 / 5218	HGNCID:	8883	Length:	469	Species:	Homo sapiens
Sequence 2:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	250/513 - (48%)
Similarity:	309/513 - (60%)	Gaps:	98/513 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    11 EKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRN----------------------CQ 53
            :|.|.::||::.||.||.|:.:.::|.  ||      ||.:                      ..
  Fly    25 KKGGALQKLKKRLSHSFGRLTISREDG--DE------STHHHHHHHHHRGGHGGHHNHGNKVPYN 81

Human    54 GMDSV-----IKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESP 113
            |.:|.     ::|...||.||      |...:...|...|       :||...:::::.:.....
  Fly    82 GYNSEEYLDRLEPNGNIPADK------TNCRYGAQESAKN-------DNNKPQDWRSTDSTDHHD 133

Human   114 KVRRHSS-------------------------PSSPTSPK------------------------- 128
            :|:|..|                         |..|..||
  Fly   134 RVQRQLSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSP 198

Human   129 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANI 193
            |||.::|.|||.||||||||||||.||:..:.||||.||||||||.||||||||||||.|||:||
  Fly   199 FGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNI 263

Human   194 VLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK 258
            |.||||:||:||||.|||||:|||.|||:||||||...||:||||||||||||.|:|.:||||:|
  Fly   264 VTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVK 328

Human   259 PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFV 323
            ||||||||.||||||||||||||||||||||:|||||||||||||||||||||.|||||||||||
  Fly   329 PQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFV 393

Human   324 EMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSY 388
            ||:.|:..|||::|..|||::||.:||||.|||||||...|.:||.:...|..:.|...:.:|..
  Fly   394 EMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYD 458

Human   389 VNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPE 446
            :...|.:|:..||.:|:.||.|..||.|.||:.||.:|:||.|.:|||||..|:|..|
  Fly   459 IIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK14	NP_001274064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..133		10/79 (13%)
		STKc_PFTAIRE1	129..431	CDD:143374	208/301 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..469
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	200/288 (69%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	198/284 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I708
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7888
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1676
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0003670
OrthoInspector	1	1.000	-	-		otm41673
orthoMCL	1	0.900	-	-		OOG6_107080
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3201
SonicParanoid	1	1.000	-	-		X2541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860