DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B1 and CG33298

DIOPT Version :9

Sequence 1:	NP_001361314.1	Gene:	ATP8B1 / 5205	HGNCID:	3706	Length:	1251	Species:	Homo sapiens
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1339	Identity:	417/1339 - (31%)
Similarity:	630/1339 - (47%)	Gaps:	330/1339 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    91 KYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVVLGVT 155
            ::..|.|:|.||...:|||.||.|||.|.|||||:.:::|..||:||.......::|:|.|||||
  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313

Human   156 AIKDLVDDVARHKMDKEINNRTCEVIKDG---RFKVAKWKEIQVGDVIRLKKNDFVPADILLLSS 217
            |:|||.:|..|...||.|||.||.|. ||   |:|..||:|::|||::.|..|:.||||||||.:
  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVY-DGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRT 377

Human   218 SEPNSLCYVETAELDGETNLKFK---------MSLEITDQYLQREDTLATFDGFIECEEPNNRLD 273
            |:|..:||::|.:||||||||.:         .|:.:..:::.|          :|.:.|..:|.
  Fly   378 SDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSR----------VEADAPTTKLY 432

Human   274 KFTGTLFW-RNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLM 337
            :|.|.|.. .....|:..:.:|||...::|||:..|:|::||.:||.|.|:...|:||::::..|
  Fly   433 RFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQM 497

Human   338 NY-MVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYDGEDDTPSYRGFLIFWGYIIVLNTMVP 401
            |. :::.:.::|||...| |||...|.:...:...........|.:.....|||.||::|..|:|
  Fly   498 NIDVIWCVIILLILCVVG-AIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIP 561

Human   402 ISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTF 466
            :||||::|:.::.|...|:.::.::.||.:...:.|...:.|:||||.:||:|||||||:|.|.|
  Fly   562 LSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIF 626

Human   467 KKCCINGQIYGDHRDASQHNH--NKIEQV--------------DFSWNTYADGKLAFYDHYLIEQ 515
            ::|.:||         |.:||  :::|::              |   |..:|........||...
  Fly   627 RRCVVNG---------SDYNHPPSELEKIYSKPGAPAPPLIPND---NLNSDMAQLTQGTYLTPH 679

Human   516 IQSGKEPEVRQFFFLLAVCHTVMV----------------------------------------- 539
            .|     .:::|..:||:|:||:|
  Fly   680 AQ-----RIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASST 739

Human   540 -----------------------DR---------------------------------------- 541
                                   ||
  Fly   740 STTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAES 804

Human   542 ----------------------------------------------------------------- 541

  Fly   805 SPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRT 869

Human   542 TDGQLNYQAASPDEGALVNAARNFGFAFLARTQNTITIS--ELGTERTYNVLAILDFNSDRKRMS 604
            .||:..|:|.||||.||||||.::....|.|:.|.|.:|  ..|..|.|.:|.:|.|:|.||.||
  Fly   870 ADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMS 934

Human   605 IIVR-TPEGNIKLYCKGADTVIYERL----HRMNP---TKQETQDALDIFANETLRTLCLCYKEI 661
            |:|| .....|.||.||||:.|...|    |. :|   .:::||..||.:|.|.||.|.:..:.:
  Fly   935 IVVRQIGSQEIVLYTKGADSSIMPVLVPCSHN-SPEGILREQTQQLLDRYAREGLRILVMAKRTL 998

Human   662 EEKEFTEWNKKFMAASVASTNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADI 726
            ...::|:|..:.....::..||:..|...:.::|.:|.|||||.|||:|||||||||:.|..|.|
  Fly   999 NSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGI 1063

Human   727 KIWVLTGDKKETAENIGFACELLTEDTTI----CYGED-----INSLLHARMENQRNRGGV-YAK 781
            .:|||||||.|||.||.::.:|.|:...:    ....|     ||..| ..|||.:....: |.:
  Fly  1064 SVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYL-TDMENDKTTSTLGYGQ 1127

Human   782 FAPPVQESFFPPGGNRALIITGSWLNEILLEKKTKRNKILKLKFPRTEEERRMRTQSKRRLEAKK 846
            .....|         |||::.|..|..||..|.       ||..|
  Fly  1128 SLRKKQ---------RALVVDGKTLTFILDPKS-------KLILP-------------------- 1156

Human   847 EQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGIS 911
                  |:.|:..|::|:|||.||.|||.:|.:||......|||||||||||:||:.|.:|||||
  Fly  1157 ------FLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGIS 1215

Human   912 GQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSA 976
            |||||||||::|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.|||..:.|:|.
  Fly  1216 GQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSG 1280

Human   977 QTAYEDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLYIVGQRDLLFNYKRFFVSLLHGV 1041
            |...:..::.|||:::||||.|.:|:.|:.|::.|.|:.|.||..|:..:.:....|::.||..:
  Fly  1281 QVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDAL 1345

Human  1042 LTSMILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIASALVITVNFQIGLDTSYWTFVNAFSIFGS 1106
            ..|:::||:.|.||       .|:......|..||.::.:........::...||.::..||..|
  Fly  1346 YQSLVIFFVALCAY-------AESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLS 1403

Human  1107 IALY--FGIMFD---FHSAG-------IHVLFPSAFQFTGTASNALRQPYIWLTIILAVAVCLLP 1159
            :..:  |.|::|   .:..|       |.|.|.||..              ||.|:|:..|.:||
  Fly  1404 LGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH--------------WLVIMLSTVVAVLP 1454

Human  1160 VVAIRFLSMTIWPSESDKI--QKHRKRLKAEE---QWQR 1193
            .:.:..:.:::.|.:|.|:  |..|:|.:.|.   .|.|
  Fly  1455 RLLLTTVRISLCPDDSTKVILQSKRERSRGEALLVTWSR 1493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B1	NP_001361314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
ATP8B1	NP_001361314.1	P-type_ATPase_APLT_Dnf-like	94..1051	CDD:319770	380/1175 (32%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/49 (49%)
		ATPase-Plipid	250..1473	CDD:273734	410/1316 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	48/92 (52%)
		Cation_ATPase	<880..965	CDD:289987	38/84 (45%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	81/265 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930