Protein Alignment PEX12 and prx-12

DIOPT Version :10

• Sequence 1: NP_000277.1
• Gene: PEX12 / 5193
• HGNCID: 8854
• Length: 359
• Species: Homo sapiens
• Sequence 2: NP_001309444.1
• Gene: prx-12 / 181331
• WormBaseID: WBGene00004197
• Length: 344
• Species: Caenorhabditis elegans
• Alignment Length: 363
• Identity: 130/363 - (35%)
• Similarity: 198/363 - (54%)
• Gaps: 47/363 - (12%)

Human    10 AASVA----DDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPTHYGFLWRWFDEIFTLLDLLL 70
            |:|::    :.|||:|:::||::|.|::||||||:||.||...|..:..:.|.|||.:.:.||:|
 Worm    11 ASSISPKTEEKQPSVFDIIAQENLATSIRPALQHLVKYLAFFKPKTFLSVHRNFDEYYIIFDLIL 75

Human    71 QQHYLSRTSASFSENFYGLKRIVMGDTHKSQRLASAGLPKQQLWKSIMFLVLL---PYLKVKLEK 132
            |.|||....|||:||||.:|||..|          .|.|.....:.||.|:.|   ||::.||.:
 Worm    76 QNHYLRNYGASFTENFYSMKRIASG----------TGNPPNDGRERIMSLITLVGWPYVENKLNQ 130

Human   133 LVSSLREEDE----YSIHPPSSRWKRFYRAFLAAYPFVNMAWEGWFLVQQLRYILGKAQHHSPLL 193
            |...|:|..|    .||:...::.::.   |:..:|::..|.:......||.|||.::..|||.|
 Worm   131 LYDRLKEVYECRSWSSINGMKAKCQKM---FVIIWPYIKTALKAVKSALQLAYILNRSSIHSPWL 192

Human   194 RLAGVQLGRLTVQDIQALEHKPAKASMMQQPARSVSEKINSALKKAVGGVALSLSTGLSVGVFFL 258
            ..:||.|..||.:|::|....|.          .:.....:.:.:.:.|:...:|...:.|:||:
 Worm   193 YFSGVILKHLTPEDLEAFNAVPL----------HLQTGFFNRIWRFILGLPGIVSRLFAYGLFFV 247

Human   259 QFLDWWYSSENQETIKSLT------ALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKTRVNDTVL 317
            ||||:.|:::    :..||      |:|:||   |....|:|.:|......||:|.|.|||||.|
 Worm   248 QFLDYMYNTD----LAKLTKTGLDGAIPSPP---HKMIISESEILSLDTNKCPICLKKRVNDTAL 305

Human   318 ATSGYVFCYRCVFHYVRSHQACPITGYPTEVQHLIKLY 355
            ..|||||||.|:..||.::..||:||.|..|||||:|:
 Worm   306 FVSGYVFCYTCINQYVNTYNKCPVTGCPANVQHLIRLF 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX12	NP_000277.1	Pex2_Pex12	26..267	CDD:398431	82/247 (33%)
		mRING_PEX12	302..355	CDD:438115	30/52 (58%)
prx-12	NP_001309444.1	Pex2_Pex12	31..256	CDD:398431	82/247 (33%)
		mRING_PEX12	290..343	CDD:438115	30/52 (58%)