Protein Alignment PEX10 and Pex2

DIOPT Version :10

• Sequence 1: NP_722540.1
• Gene: PEX10 / 5192
• HGNCID: 8851
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_648210.1
• Gene: Pex2 / 38941
• FlyBaseID: FBgn0035876
• Length: 281
• Species: Drosophila melanogaster
• Alignment Length: 314
• Identity: 69/314 - (21%)
• Similarity: 111/314 - (35%)
• Gaps: 94/314 - (29%)

Human    72 EYV-SIIQVDPSRIH--VPSSLRRGVLVTLHAVLPYLLDKALLPLEQELQADPDSGRPLQGSL-- 131
            :|| .:.|:|...::  :...:|..:|..|.|:.|.|.          ::..|:....:|.::
  Fly     5 KYVPRVNQIDAIYLNKDIARLIRDNLLENLQAISPVLF----------IKIQPELDLIIQSAIWF 59

Human   132 GPGGRGCS----------------GARRWMRHHTATL------TEQQRRALLR------AVFVLR 168
            |..|:.||                ...|.:.|...|:      :.::||...|      |:..:.
  Fly    60 GSVGKRCSTFGQQLLVLAYDAEKLTVSRLVLHFILTVLPGYVKSWEERRLTRRVEWFSEAIMWVE 124

Human   169 QGLACLQRLHVAWFYIHGVFYHLAKRLTGITYQALRPDPLRVLMSVAPSALQLRVRSLPGEDLRA 233
            .....|..|:...|...|....|...|.|:.|.:||                        .:.|.
  Fly   125 NSALILNILNYFRFLKTGRKPTLVDYLLGLDYISLR------------------------NNQRR 165

Human   234 RVSYRLL-------GVISLLHLVLSMGLQLYGFRQRQRARKEWRLHRGLSHRRASLEER------ 285
            .:.|:.|       |.:.:|.||    |.:..||:.||..|.|.    .|.||  ||:|
  Fly   166 DIGYKYLTRELLWGGFMEILGLV----LPIINFRKLQRVLKSWT----FSGRR--LEDRDGPAFL 220

Human   286 --AVSRNPLCTLCLEERRHPTATPCGHLFCWECITAWCSSKAE--CPLCREKFP 335
              .::.:..||.|.|....|....|||::|:.|:.|...:.|.  ||.|....|
  Fly   221 APQMTLSTTCTFCGERPTLPHHMGCGHIYCYYCLNANVLTDASFCCPNCGSACP 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX10	NP_722540.1	Pex2_Pex12	18..263	CDD:398431	43/230 (19%)
		RING-HC_PEX10	293..342	CDD:438190	16/45 (36%)
Pex2	NP_648210.1	Pex2_Pex12	22..207	CDD:398431	43/226 (19%)
		RING-HC_PEX2	227..273	CDD:438189	15/45 (33%)